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C8982
α-Cyano-4-hydroxycinnamic acid
suitable for MALDI-TOF MS
Synonym(s):
α-CCA, α-CHCA, α-Cyano, 4-HCCA, ACCA
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10 X 10 MG
$303.00
$303.00
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About This Item
Linear Formula:
HOC6H4CH=C(CN)CO2H
CAS Number:
Molecular Weight:
189.17
UNSPSC Code:
12352106
NACRES:
NA.21
PubChem Substance ID:
EC Number:
248-879-1
Beilstein/REAXYS Number:
3271427
MDL number:
Form:
powder
Quality level:
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InChI key
AFVLVVWMAFSXCK-VMPITWQZSA-N
InChI
1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)/b8-5+
SMILES string
OC(=O)\C(=C\c1ccc(O)cc1)C#N
form
powder
analyte chemical class(es)
glycans, peptides, proteins
Quality Level
mp
245-250 °C (lit.)
suitability
suitable for MALDI-TOF MS
storage temp.
room temp
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Related Categories
1 of 4
This Item | |||
|---|---|---|---|
| form powder | form solid | form solid | form powder |
| Quality Level 500 | Quality Level 100 | Quality Level 100 | Quality Level 300 |
| storage temp. room temp | storage temp. 2-8°C | storage temp. - | storage temp. 2-8°C |
| analyte chemical class(es) glycans, peptides, proteins | analyte chemical class(es) glycans, peptides, proteins | analyte chemical class(es) glycans, peptides, proteins | analyte chemical class(es) - |
| mp 245-250 °C (lit.) | mp 245-250 °C (lit.) | mp 245-250 °C (lit.) | mp 245-250 °C (lit.) |
| suitability suitable for MALDI-TOF MS | suitability - | suitability - | suitability - |
General description
α-Cyano-4-hydroxycinnamic acid (CHCA) is specially purified and qualified as a matrix for peptide MALDI-MS (matrix assisted laser desorption ionization-mass spectrometry) calibration standards. CHCA enhances ionization of protein or peptide standards and samples in matrix assisted laser desorption ionization (MALDI) mass spectrometers.[1]
It is also available as part of our ProteoMass™ MALDI calibration kits (MS-CAL1 and MS-CAL3).
It is also available as part of our ProteoMass™ MALDI calibration kits (MS-CAL1 and MS-CAL3).
Application
α-Cyano-4-hydroxycinnamic acid has been used as a matrix for MALDI-TOF MS (matrix assisted laser desorption ionization-time of flight mass spectrometry) analysis. The matrix has also been used for sample preparation.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Legal Information
ProteoMass is a trademark of Sigma-Aldrich Co. LLC
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Pricing
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Warning
hcodes
Hazard Classifications
Skin Sens. 1B
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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MALDI-TOF MS sample preparation by using alkanethiolate self-assembled monolayers: A preliminary application for protein sample analysis.
Tyan Y-C, et al.
International Journal of Mass Spectrometry, 262, 67-72 (2007)
a-Cyano-4-hydroxycinnamic acid as a matrix for matrixassisted laser desorption mass spectromtry.
Beavis RC, et al.
Journal of Mass Spectrometry : Jms, 27, 156-158 (1992)
Utilizing isotope dilution-matrix-assisted laser desorption ionization-time of flight mass spectrometry as a reference procedure for the radioimmunoassay of serum thyroxine.
Tyan YC, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 420, 99-103 (2013)
The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), a-, and ?-melanocyte stimulating hormone (a-MSH, and ?-MSH), and the conserved core motif HFRW.
N?hr AC, et al.
Neurochemistry International, 102, 105-113 (2017)
Jarod A Fincher et al.
The Analyst, 145(21), 6910-6918 (2020-08-26)
Mass spectrometry imaging (MSI) is a powerful analytical technique that enables detection, discovery, and identification of multiple classes of biomolecules, while simultaneously mapping their spatial distributions within a sample (e.g., a section of biological tissue). The limitation in molecular coverage
Protocols
Explore mass spectrometry analysis of glycans for glycomic & glycoproteomic neutral & acidic glycan analysis. See a general mass spec glycan analysis procedure.
Related Content
Glycobiology and Glycoproteomics Brochure
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What can be used for solublization of α-Cyano-4-hydroxycinnamic acid?
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α-Cyano-4-hydroxycinnamic acid (α-CCA, α-CHCA, α-Cyano, 4-HCCA, ACCA) is soluble in methanol (up to 50 mg/ml). It is also soluble at 10 mg/ml using 50% acetonitrile in 0.05% TFA for MALDI-MS. The acetonitrile concentration can be adjusted for individual preferences.For biological applications, it has been solubilized at 100 mM in DMSO or 50 mM in ethanol.
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