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C8679

Sigma-Aldrich

Chicago Sky Blue 6B

powder

Synonym(s):

Direct Blue 1, Pontamine sky blue

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25 G
$219.00

$219.00


Estimated to ship onMarch 28, 2025


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25 G
$219.00

About This Item

Empirical Formula (Hill Notation):
C34H24N6Na4O16S4
CAS Number:
Molecular Weight:
992.80
Colour Index Number:
24410
EC Number:
MDL number:
UNSPSC Code:
12171500
PubChem Substance ID:
NACRES:
NA.47

$219.00


Estimated to ship onMarch 28, 2025


Request a Bulk Order

form

powder

Quality Level

composition

Dye content, ~80%

color

blue

solubility

H2O: 10 mg/mL

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

[Na+].[Na+].[Na+].[Na+].COc1cc(ccc1\N=N\c2ccc3c(cc(c(N)c3c2O)S([O-])(=O)=O)S([O-])(=O)=O)-c4ccc(\N=N\c5ccc6c(cc(c(N)c6c5O)S([O-])(=O)=O)S([O-])(=O)=O)c(OC)c4

InChI

1S/C34H28N6O16S4.4Na/c1-55-23-11-15(3-7-19(23)37-39-21-9-5-17-25(57(43,44)45)13-27(59(49,50)51)31(35)29(17)33(21)41)16-4-8-20(24(12-16)56-2)38-40-22-10-6-18-26(58(46,47)48)14-28(60(52,53)54)32(36)30(18)34(22)42;;;;/h3-14,41-42H,35-36H2,1-2H3,(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54);;;;/q;4*+1/p-4/b39-37+,40-38+;;;;

InChI key

BPHHNXJPFPEJOF-GPTZEZBUSA-J

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application

Chicago Sky Blue 6B is a counterstain for background autofluorescence in fluorescence and immunofluorescence histochemistry.[1] It has also been used as a filling in glass pipette electrodes for electrophysiological recordings in the brain sections of rats.[2][3]

Biochem/physiol Actions

Chicago Sky Blue 6B is a large organic acid, structurally related to glutamate, that is a potent and efficient competitive inhibitor of vesicular glutamate uptake.[4]

pictograms

Health hazard

signalword

Danger

hcodes

Hazard Classifications

Carc. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Responses to tactile stimulation in deep cerebellar nucleus neurons result from recurrent activation in multiple pathways.
Rowland NC and Jaeger D
Journal of Neurophysiology, 99, 704-704 (2008)
Li Hang Qi et al.
Human gene therapy, 20(7), 739-750 (2009-03-13)
Because both Toll-like receptor-1 (TLR1) and TLR2 are expressed in atherosclerotic plaques, we hypothesized that TLR1 and TLR2 may play different roles in the formation of vulnerable plaques and that combinatorial knockdown of TLR1 and TLR2 genes may enhance the
S Roseth et al.
Journal of neurochemistry, 65(1), 96-103 (1995-07-01)
In this study we have described a series of new and potent inhibitors of the vesicular uptake of glutamate. The two most efficient inhibitors were the dyes Evans blue and Chicago Skye Blue 6B, which are structurally related to glutamate
Resonant antidromic cortical circuit activation as a consequence of high-frequency subthalamic deep-brain stimulation.
Li S, et al.
Journal of Neurophysiology, 98, 3525-3525 (2007)
Detection of aromatase in human endometrial tissue cultured in three-dimensional fibrin matrix in vitro.
Jafar A, et al.
International journal of reproductive biomedicine (Yazd, Iran), 7, 105-109 (2009)

Questions

  1. Hi, I need to know information to Chicago Sky Blue - is available declaration of conformity for this stain? New requirtments regulation of IVDR.

    1 answer
    1. This product is intended for research use only. It is not suitable for In Vitro Diagnostic use. The only documents available for this item are the product Certificate of Analysis, Certificate of Origin, and Safety Data Sheet are routinely available.
      Please see the link below to review additional information regarding product Quality Level Assignments and the associated documentation for each level.
      https://www.sigmaaldrich.com/life-science/quality-and-regulatory-management/m-clarity-program

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