C4680

α-Cyclodextrin

powder, BioReagent, suitable for cell culture, ≥98%

• Synonym(s): α-Schardinger dextrin, Cyclohexaamylose, Cyclomaltohexaose
• Empirical Formula (Hill Notation): C₃₆H₆₀O₃₀
• CAS Number: 10016-20-3
• Molecular Weight: 972.84
• Beilstein/REAXYS Number: 79627
• EC Number: 233-007-4
• MDL number: MFCD00078207
• UNSPSC Code: 12352201
• PubChem Substance ID: 24892712
• NACRES: NA.77

Properties

• sterility: non-sterile
• product line: BioReagent
• assay: ≥98%
• form: powder
• technique(s): cell culture | mammalian: suitable
• mp: >278 °C (dec.) (lit.)
• solubility: H₂O: 10 mg/mL
• shipped in: ambient
• storage temp.: room temp
• SMILES string: OC[C@H]1O[C@@H]2O[C@H]3[C@H](O)[C@@H](O)[C@H](O[C@@H]3CO)O[C@H]4[C@H](O)[C@@H](O)[C@H](O[C@@H]4CO)O[C@H]5[C@H](O)[C@@H](O)[C@H](O[C@@H]5CO)O[C@H]6[C@H](O)[C@@H](O)[C@H](O[C@@H]6CO)O[C@H]7[C@H](O)[C@@H](O)[C@H](O[C@@H]7CO)O[C@H]1[C@H](O)[C@H]2O
• InChI: 1S/C36H60O30/c37-1-7-25-13(43)19(49)31(55-7)62-26-8(2-38)57-33(21(51)15(26)45)64-28-10(4-40)59-35(23(53)17(28)47)66-30-12(6-42)60-36(24(54)18(30)48)65-29-11(5-41)58-34(22(52)16(29)46)63-27-9(3-39)56-32(61-25)20(50)14(27)44/h7-54H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-/m1/s1
• InChI key: HFHDHCJBZVLPGP-RWMJIURBSA-N

Description

General description

α-Cyclodextrin (α-CD) is a cyclic oligosaccharide that consists of six glucopyranose units linked by α-(1,4) bonds.[1] α-CD acts as a soluble dietary fiber and hence it is preferred to be widely used in food industry.[2]

Application

Useful for the solubilization of nonpolar macromolecules such as fatty acids, lipids, and cholesterol for use in cell culture applications. α-Cyclodextrin has been used to solubilize odanacatib, a cathepsin K inhibitor.[3]

Biochem/physiol Actions

α-Cyclodextrin is found to form a firm complex with dietary fats. This way it decreases the bioavailability and absorption of fats. It is known to regulate triglyceride and leptin levels in serum. In rat models, α-Cyclodextrin is shown to induce insulin sensitivity and fecal fat excretion. Thus, α-cyclodextrin is considered to be effective for treating obesity and metabolic syndromes.[2]

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)