C4285
Acetyl-Calpastatin (184-210) human
~95% (HPLC), powder
Synonym(s):
Acetyl-Calpain inhibitor fragment 184-210, CS peptide
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About This Item
Empirical Formula (Hill Notation):
C142H230N36O44S
CAS Number:
Molecular Weight:
3177.63
UNSPSC Code:
12352200
MDL number:
Biochem/physiol Actions
Inhibitor of calpain which induces an increase in secreted amyloid β-protein 1-42.
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Robert L Campbell et al.
The Biochemical journal, 447(3), 335-351 (2012-10-06)
Calpains are a family of complex multi-domain intracellular enzymes that share a calcium-dependent cysteine protease core. These are not degradative enzymes, but instead carry out limited cleavage of target proteins in response to calcium signalling. Selective cutting of cytoskeletal proteins
Wilasinee Suwanjang et al.
Neuroscience letters, 526(1), 49-53 (2012-08-18)
Methamphetamine (METH) is an abused psychostimulant drug that can cause neurotoxicity to dopaminergic cells. It has been demonstrated that METH can induce caspase- and calpain-dependent death cascades. The purpose of the present study was to investigate the functional role of
Amy L Strong et al.
Stem cells (Dayton, Ohio), 30(12), 2774-2783 (2012-09-13)
Adipose tissue maintains a subpopulation of cells, referred to as adipose-derived stromal/stem cells (ASCs), which have been associated with increased breast cancer tumorigenesis and metastasis. For ASCs to affect breast cancer cells, it is necessary to delineate how they mobilize
Tiziana Latronico et al.
PloS one, 8(2), e49656-e49656 (2013-02-08)
Proteolytic enzymes have been implicated in the pathogenesis of Multiple Sclerosis (MS) for both their ability to degrade myelin proteins and for their presence in MS plaques.In this study we investigated whether interferon-beta (IFN-β) could differently modulate the activity and
Meredith Kohr Owen et al.
Circulation, 128(1), 9-18 (2013-05-21)
This investigation examined the mechanisms by which coronary perivascular adipose tissue (PVAT)-derived factors influence vasomotor tone and the PVAT proteome in lean versus obese swine. Coronary arteries from Ossabaw swine were isolated for isometric tension studies. We found that coronary
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