C1623
Anti-CLIC2 (233-247) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
Synonym(s):
Anti-CLIC2b, Anti-Chloride intracellular channel protein 2, Anti-XAP121
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About This Item
UNSPSC Code:
12352203
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~28 kDa
species reactivity
human
technique(s)
western blot: 1:500-1:2,000
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CLIC2(1193)
General description
Chloride intracellular channel protein 2 is a protein encoded by the CLIC2 gene in humans and belongs to chloride intracellular channel (CLIC) family. It is also referred as CLIC2b, MRXS32 and XAP121. CLIC2 protein is a member of the glutathione transferase class of proteins and they can exist as integral membrane-channel form or a soluble form. The gene is possibly associated with one of the many diseases linked to Xq28.
Immunogen
synthetic peptide corresponding to amino acids 233-247 of human CLIC2
Application
Anti-CLIC2 (233-247) antibody produced in rabbit is suitable for western blotting at a dilution of 1:500-1:2,000.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.
Biochem/physiol Actions
Chloride intracellular channel 2 (CLIC2) functions by regulating ryanodine receptor (RyR) intracellular Ca(2+) release channels. RyR proteins play a major role in the regulation of Ca(2+) signaling in many cells. CLIC2 protein also helps in maintaining normal cognitive function by interacting with RyRs in the brain. In healthy individuals it is studied that the CLIC2 protein can tolerate amino acid substitutions and can be fully functional.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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Kyoko Takano et al.
Human molecular genetics, 21(20), 4497-4507 (2012-07-21)
Chloride intracellular channel 2 (CLIC2) protein is a member of the glutathione transferase class of proteins. Its' only known function is the regulation of ryanodine receptor (RyR) intracellular Ca(2+) release channels. These RyR proteins play a major role in the
N S Heiss et al.
Genomics, 45(1), 224-228 (1997-10-27)
A transcript map was previously constructed in the 1200-kb telomeric region of Xq28. One of the cDNAs, XAP121, displayed homology to a p64 bovine chloride channel and to a human chloride channel (p64CLCP, NCC27) at both the nucleotide and the
Brett A Cromer et al.
Acta crystallographica. Section F, Structural biology and crystallization communications, 63(Pt 11), 961-963 (2007-11-17)
The chloride intracellular channel (CLIC) family of proteins are unusual in that they can exist in either an integral membrane-channel form or a soluble form. Here, the expression, purification, crystallization and preliminary diffraction analysis of CLIC2, one of the least-studied
Shawn Witham et al.
Proteins, 79(8), 2444-2454 (2011-06-02)
Large-scale next generation resequencing of X chromosome genes identified a missense mutation in the CLIC2 gene on Xq28 in a male with X-linked intellectual disability (XLID) and not found in healthy individuals. At the same time, numerous nsSNPs (nonsynonomous SNP)
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