This material has not been tested for the suitability in cell culture. However, this product has been used successfully by other scientists in cell-based assays, as highlighted in the 'PEER REVIEWED PAPERS' section above. Please see the link below to review one cited publication:
Antitumor properties of aloe-emodin and induction of transglutaminase 2 activity in B16–F10 melanoma cells
https://www.sciencedirect.com/science/article/pii/S0024320510002900?via%3Dihub
B6906
Aloin
from Aloe barbadensis Miller leaves, ≥97%
Synonym(s):
1,8-Dihydroxy-10-(β-D-glucopyranosyl)-3-(hydroxymethyl)-9(10H)-anthracenone, 10-β-D-Glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-9(10H)-anthracenone, Aloin A, Barbaloin
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About This Item
Empirical Formula (Hill Notation):
C21H22O9
CAS Number:
Molecular Weight:
418.39
UNSPSC Code:
12352201
NACRES:
NA.25
PubChem Substance ID:
EC Number:
215-808-0
Beilstein/REAXYS Number:
6077558
MDL number:
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biological source
Aloe barbadensis Miller leaves
Quality Level
assay
≥97%
form
powder
solubility
methanol: 100 mg/mL, clear to very slightly hazy, light yellow to yellow
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
2-8°C
SMILES string
OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)[C@H]2c3cccc(O)c3C(=O)c4c(O)cc(CO)cc24
InChI
1S/C21H22O9/c22-6-8-4-10-14(21-20(29)19(28)17(26)13(7-23)30-21)9-2-1-3-11(24)15(9)18(27)16(10)12(25)5-8/h1-5,13-14,17,19-26,28-29H,6-7H2/t13-,14+,17-,19+,20-,21+/m1/s1
InChI key
AFHJQYHRLPMKHU-OSYMLPPYSA-N
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Related Categories
1 of 4
This Item | |||
|---|---|---|---|
| form powder | form powder | form - | form - |
| biological source Aloe barbadensis Miller leaves | biological source Curacao aloe | biological source - | biological source - |
| assay ≥97% | assay - | assay ≥95.0% (HPLC) | assay - |
| application(s) metabolomics | application(s) - | application(s) food and beverages | application(s) pharmaceutical (small molecule) |
| Quality Level 200 | Quality Level 100 | Quality Level - | Quality Level - |
| storage temp. 2-8°C | storage temp. room temp | storage temp. 2-8°C | storage temp. 2-8°C |
Application
Aloin, a natural mixed diastereomer (A/B) anthracycline from aloe plant, may be studied as a chemopreventive factor and antineoplastic agent. Aloin inhibits angiogenesis, enhances melanogenesis and regulates transglutaminase activity.[1] Aloin may be used to assess its activity as a selective phosphodiesterase inhibitor. Aloin A is used as a stabilizer in the preparation of gold and silver nanoparticles.[2]
Biochem/physiol Actions
Purgative activity in rats requires activation by Eubacterium sp. strain BAR or similar intestinal anaerobe, presumably by conversion to aloe-emodin anthrone.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Angelo Gismondi et al.
Amino acids, 38(1), 257-262 (2009-02-13)
The aim of this study was to collect evidences on the role of transglutaminase (TG, E.C.2.3.2.13) in the antineoplastic properties exerted by nimesulide (NMS), a non-steroidal anti-inflammatory drug, on murine B16-F10 melanoma cells. Treatment of melanoma cells with nimesulide produces
Mi-Young Park et al.
Nutrition research and practice, 2(1), 17-21 (2008-04-01)
Aloin is a physiologically active anthraquinone present in aloe. There are two isomers of aloin, aloin A and aloin B, occurring as a mixture of diastereomers. The objective of this study was to determine the bioavailability and tissue distribution of
Aloin enhances cisplatin antineoplastic activity in B16-F10 melanoma cells by transglutaminase-induced differentiation.
Tabolacci C, Rossi S, Lentini A, et al.
Amino Acids, doi: 10-doi: 10 (2011)
Zeljka Krpetić et al.
Langmuir : the ACS journal of surfaces and colloids, 25(13), 7217-7221 (2009-06-10)
A novel use of two components of Cape aloe, aloin A and aloesin, acting as stabilizers in the preparation of gold and silver nanoparticles, is reported. Stable water-soluble particles of different size and shape are prepared by varying the reaction
Mahmoud A Elsohly et al.
Journal of AOAC International, 90(1), 28-42 (2007-03-22)
Methods using liquid chromatography/mass spectrometry (LC/MS) and LC with diode array detection (DAD) in the UV range (LC/UV) were developed for the determination of low levels of the anthraquinones aloe-emodin and aloin-A (barbaloin) in aloe-based products. The methods were used
Global Trade Item Number
| SKU | GTIN |
|---|---|
| B6906-100MG | 04061835366163 |
| B6906-25MG | 04061835366170 |
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Can this be used for cell culture experiment
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How can I determine the shelf life / expiration / retest date of this product?
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If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
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For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdfHelpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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I studied some papers and found that aloin is a light sensitive compound, is it true?
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This material is considered light and air sensisitve. The product is packaged under nitrogen in white HDPE bottles.
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