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B4311

BF-170 hydrochloride

≥98% (HPLC), solid

Synonym(s):

2-(4-aminophenyl)quinoline hydrochloride, NSC 168387 hydrochloride

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Pack SizeSKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$129.00
25 mg

Available to ship TODAYfromMILWAUKEE

$441.00

About This Item

Empirical Formula (Hill Notation):
C15H12N2 · HCl
CAS Number:
22191-97-5
Molecular Weight:
256.73
NACRES:
NA.77
PubChem Substance ID:
24891766
UNSPSC Code:
12352200
MDL number:
MFCD08705340
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
desiccated, protect from light, under inert gas

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Quality Segment

100

assay

≥98% (HPLC)

form

solid

storage condition

desiccated, protect from light, under inert gas

color

orange

solubility

H2O: 10 mg/mL

storage temp.

−20°C

SMILES string

Cl[H].Nc1ccc(cc1)-c2ccc3ccccc3n2

InChI

1S/C15H12N2.ClH/c16-13-8-5-12(6-9-13)15-10-7-11-3-1-2-4-14(11)17-15;/h1-10H,16H2;1H

InChI key

UYYPMQOFLJHJAW-UHFFFAOYSA-N

Biochem/physiol Actions

BF-170 is a new probe for neurofibrillary tangles (tau fibrils) with greater binding affinity to tau than to Aβ fibrils.
BF-170 is a new probe for neurofibrillary tangles (tau fibrils). It exhibits greater binding affinity to tau than to Aβ fibrils, EC50 = 221 nM vs. EC50 = 786 nM (Ki for Aβ > 5,000 nM). BF-170 demonstrates fast clearance from the brain; clearly visualizes neurofibrillary tangles, neuropil threads, and paired helical filament-type neuritis. BF-70 may become one of the candidate compounds for in vivo imaging of tau pathology associated with Alzheimer′s disease and is a useful tool in distinguishing among tau and Aβ fibrils specifically in AD.

Disclaimer

Product is air sensitive, store under inert gas.

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This Item
B154N142P3998
BF-170 hydrochloride ≥98% (HPLC), solid

Sigma-Aldrich

B4311

BF-170 hydrochloride

BU224 hydrochloride solid

Sigma-Aldrich

B154

BU224 hydrochloride

NO-711 hydrochloride ≥98% (HPLC)

Sigma-Aldrich

N142

NO-711 hydrochloride

PGL-135 hydrochloride monohydrate ≥98% (HPLC), solid

Sigma-Aldrich

P3998

PGL-135 hydrochloride monohydrate

form

solid

form

solid

form

powder

form

solid

assay

≥98% (HPLC)

assay

-

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

-

storage temp.

−20°C

storage temp.

-

storage temp.

-

storage temp.

2-8°C

storage condition

desiccated, under inert gas, protect from light

storage condition

-

storage condition

desiccated, protect from light

storage condition

desiccated, protect from light, under inert gas

solubility

H2O: 10 mg/mL

solubility

ethanol: 1.2 mg/mL, H2O: >16 mg/mL, 0.1 M NaOH: 24 mg/mL, 0.1 M HCl: >30 mg/mL

solubility

H2O: 10 mg/mL at 60 °C

solubility

DMSO: >5 mg/mL, H2O: insoluble

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
046K46021
046K4602

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Global Trade Item Number

SKUGTIN
B4311-25MG04061832977089
B4311-5MG04061832977096

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