A7475
Anthopleurin-A trifluoroacetate salt
>88% (HPLC)
Synonym(s):
AP-A trifluoroacetate salt, Anthopleura toxin A trifluoroacetate salt
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About This Item
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assay
>88% (HPLC)
form
solid
storage temp.
−20°C
Amino Acid Sequence
Gly-Val-Ser-Cys-Leu-Cys-Asp-Ser-Asp-Gly-Pro-Ser-Val-Arg-Gly-Asn-Thr-Leu-Ser-Gly-Thr-Leu-Trp-Leu-Tyr-Pro-Ser-Gly-Cys-Pro-Ser-Gly-Trp-His-Asn-Cys-Lys-Ala-His-Gly-Pro-Thr-Ile-Gly-Trp-Cys-Cys-Lys-Gln [Disulfide bridges: 4-46, 6-36, 29-47]
General description
Synthetic peptide toxin that was originally isolated from the sea anemone, Anthopleura xanthogrammica.
Application
Anthopleurin-A is a toxin used to study the gating mechanisms of sodium channels. Anthopleurin-A slows the repolarization phase of nerve and muscle action potentials by inactivating the sodium channel.
Biochem/physiol Actions
Anthopleurin-A slows the repolarization phase of nerve and muscle action potentials by inactivating the sodium channel. Anthopleurin-A shows a preference towards cardiac channels over the neuronal sodium channels. It is a toxin used to study the gating mechanisms of sodium channels.
Shown to have inotropic effects and not chronotropic effects on mammalian heart preparations.
Other Notes
supplied as trifluoroacetate salt
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Certificates of Analysis (COA)
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Biochemistry, 34(11), 3782-3794 (1995-03-21)
The three-dimensional structure in aqueous solution of the 49-residue polypeptide anthopleurin-A (AP-A), from the sea anemone Anthopleura xanthogrammica, has been determined from 1H NMR data. A restraint set consisting of 411 interproton distance restraints inferred from NOEs and 19 backbone
Journal of physiology, Paris, 89(4-6), 171-180 (1995-01-01)
The physiological function of the axon is to conduct short all-or-none action potentials from their site of initiation (usually the cell body) to the synapse. To ensure this function, both passive and active biophysical properties of the axons are tuned
Protein science : a publication of the Protein Society, 3(7), 1121-1124 (1994-07-01)
Anthopleurin-A (AP-A) is a member of a family of sea anemone-derived polypeptides that interact with sodium channels in a voltage-dependent manner, producing a positive inotropic effect on the mammalian heart. There has been considerable interest in this molecule as a
Circulation, 96(6), 2038-2047 (1997-10-10)
This study examines the contribution of transmural heterogeneity of transmembrane activity to phenotypic T-wave patterns and the effects of pacing and of sodium channel block under conditions mimicking HERG and SCN5A defects linked to the congenital long-QT syndrome (LQTS). A
Pacing and clinical electrophysiology : PACE, 20(8 Pt 2), 2052-2057 (1997-08-01)
The long QT syndrome (LQTS) is a familial disease characterized by prolonged ventricular repolarization and high incidence of malignant ventricular tachyarrhythmias often occurring in conditions of adrenergic activation. Recently, the genes for the LQTS inked to chromosomes 3 (LQT3), 7
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