A3133

N_α-Acetyl-L-arginine

Name: <I>N</I><SUB>&#945;</SUB>-Acetyl-<SC>L</SC>-arginine
Brand: SIGMA

≥98% (TLC), suitable for deacetylase assays

Synonym(s):

N²-acetyl-L-alanine

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About This Item

Empirical Formula (Hill Notation):

C₈H₁₆N₄O₃

CAS Number:

155-84-0

Molecular Weight:

216.24

UNSPSC Code:

12352209

eCl@ss:

32160406

PubChem Substance ID:

24890487

NACRES:

NA.26

EC Number:

205-846-6

MDL number:

MFCD00019733

Key Documents

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Product Name

N_α-Acetyl-L-arginine,

assay

≥98% (TLC)

Quality Level

200

form

powder

technique(s)

deacetylase assay: suitable

color

colorless to white

storage temp.

−20°C

SMILES string

NC(NCCC[C@H](NC(C)=O)C(O)=O)=N

InChI

1S/C8H16N4O3/c1-5(13)12-6(7(14)15)3-2-4-11-8(9)10/h6H,2-4H2,1H3,(H,12,13)(H,14,15)(H4,9,10,11)/t6-/m0/s1

InChI key

SNEIUMQYRCDYCH-LURJTMIESA-N

Related Categories

Amino Acids – Building Blocks of Life Science

Biochemicals

Cell Culture Supplements & Reagents

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This Item	A3626	A2010	A2628
Sigma-Aldrich A3133 N_α-Acetyl-L-arginine	Sigma-Aldrich A3626 N_α-Acetyl-L-ornithine	Sigma-Aldrich A2010 N_α-Acetyl-L-lysine	Sigma-Aldrich A2628 L-Alanine β-naphthylamide
form powder	form powder	form powder	form powder
assay ≥98% (TLC)	assay ≥98% (TLC)	assay ≥98% (TLC)	assay ≥98% (TLC)
technique(s) deacetylase assay: suitable	technique(s) ligand binding assay: suitable	technique(s) ligand binding assay: suitable	technique(s) -
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
color colorless to white	color colorless to white	color colorless to white	color -

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Binding and modification of proteins by methylglyoxal under physiological conditions. A kinetic and mechanistic study with N alpha-acetylarginine, N alpha-acetylcysteine, and N alpha-acetyllysine, and bovine serum albumin.

T W Lo et al.

The Journal of biological chemistry, 269(51), 32299-32305 (1994-12-23)

The physiological alpha-oxoaldehyde methylglyoxal binds and modifies arginine, lysine, and cysteine residues in proteins. The kinetics and mechanism of these reactions were investigated with N alpha-acetylamino acids and bovine serum albumin at pH 7.4 and 37 degrees C. The reaction

In vitro effects of L-arginine and guanidino compounds on NTPDase1 and 5'-nucleotidase activities from rat brain synaptosomes.

Daniela Balz et al.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 21(2), 75-82 (2003-03-05)

Tissue accumulation of arginine (Arg), N-acetylarginine (NA), argininic acid (AA) and homoarginine (HA) occurs in hyperargininemia, an inborn error of the urea cycle. In the present study, we investigated the in vitro effects of Arg, NA, AA and HA on

Binding of methylglyoxal to albumin and formation of fluorescent adducts. Inhibition by arginine, N-alpha-acetylarginine and aminoguanidine.

T Selwood et al.

Biochemical Society transactions, 21(2), 170S-170S (1993-05-01)

In vitro stimulation of oxidative stress in cerebral cortex of rats by the guanidino compounds accumulating in hyperargininemia.

A T Wyse et al.

Brain research, 923(1-2), 50-57 (2001-12-18)

Hyperargininemia is a metabolic disorder biochemically characterized by tissue accumulation of arginine and other guanidino compounds. Convulsions, lethargy and psychomotor delay or cognitive deterioration are predominant clinical features of this disease. Although neurologic symptoms predominate in this disorder, their pathophysiology

Serum guanidino compound levels in uremic pediatric patients treated with hemodialysis or continuous cycle peritoneal dialysis. Correlations between nerve conduction velocities and altered guanidino compound concentrations.

P P De Deyn et al.

Nephron, 69(4), 411-417 (1995-01-01)

Serum levels of twelve guanidino compounds (GCs) and nerve conduction velocities were determined in a dialyzed renal insufficient pediatric population. Two dialytic groups were considered: one subjected to hemodialysis (HD, 11 patients) and one subjected to continuous cycle peritoneal dialysis

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Global Trade Item Number

SKU	GTIN
A3133-10G	04061832414737
A3133-5G	04061832414744

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N_α-Acetyl-L-arginine