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A3105

Sigma-Aldrich

2-Amino-N-quinolin-8-yl-benzenesulfonamide

≥98% (HPLC), solid

Synonym(s):

QBS

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About This Item

Empirical Formula (Hill Notation):
C15H13N3O2S
CAS Number:
16082-64-7
Molecular Weight:
299.35
MDL number:
MFCD00168987
UNSPSC Code:
12352200
PubChem Substance ID:
24724388

assay

≥98% (HPLC)

form

solid

solubility

DMSO: soluble 22 mg/mL
H2O: insoluble

SMILES string

Nc1ccccc1S(=O)(=O)Nc2cccc3cccnc23

InChI

1S/C15H13N3O2S/c16-12-7-1-2-9-14(12)21(19,20)18-13-8-3-5-11-6-4-10-17-15(11)13/h1-10,18H,16H2

InChI key

NIOOKXAMJQVDGB-UHFFFAOYSA-N

Biochem/physiol Actions

Inhibitor of cell cycle at G2 phase; apoptosis inducer.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Yun-Hee Kim et al.
Biochemical pharmacology, 69(9), 1333-1341 (2005-04-14)
We screened a library of 11,000 small molecular weight chemicals, looking for compounds that affect cell viability. We have identified 2-amino-N-quinoline-8-yl-benzenesulfonamide (QBS) as a potent cytotoxic compound that induces cell cycle arrest and apoptosis. Treatment of Jurkat T cells with
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