A255

A-77636 hydrochloride hydrate

Name: A-77636 hydrochloride hydrate
Brand: SIGMA
Price: 430 USD

≥98% (HPLC), solid

Synonym(s):

(−)-(1R,3S)-3-Adamantyl-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyran hydrochloride hydrate

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10 MG

$430.00

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₂₇NO₃ · HCl · xH₂O

CAS Number:

145307-34-2

Molecular Weight:

365.89 (anhydrous basis)

UNSPSC Code:

12352200

PubChem Substance ID:

24277883

NACRES:

NA.77

Key Documents

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Product Name

A-77636 hydrochloride hydrate, ≥98% (HPLC), solid

SMILES string

O.Cl.NC[C@@H]1O[C@@H](Cc2c(O)c(O)ccc12)C34CC5CC(CC(C5)C3)C4

InChI

1S/C20H27NO3.ClH.H2O/c21-10-17-14-1-2-16(22)19(23)15(14)6-18(24-17)20-7-11-3-12(8-20)5-13(4-11)9-20;;/h1-2,11-13,17-18,22-23H,3-10,21H2;1H;1H2/t11?,12?,13?,17-,18-,20?;;/m0../s1

InChI key

KNACNUUSUYTFDY-LIWDBWMRSA-N

assay

≥98% (HPLC)

form

solid

storage condition

desiccated
protect from light

color

white to off-white

solubility

H₂O: >10 mg/mL

storage temp.

−20°C

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Show Differences

1 of 4

This Item	H4413	A8106	E8284
Sigma-Aldrich A255 A-77636 hydrochloride hydrate	Sigma-Aldrich H4413 Hydroxyfasudil hydrochloride hydrate	Sigma-Aldrich A8106 Altanserin hydrochloride hydrate	Sigma-Aldrich E8284 (E/Z)-Endoxifen Hydrochloride Hydrate
form solid	form solid	form solid	form solid
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
storage condition desiccated, protect from light	storage condition -	storage condition -	storage condition desiccated
solubility H₂O: >10 mg/mL	solubility H₂O: >5 mg/mL	solubility DMSO: >5 mg/mL, H₂O: insoluble	solubility DMSO: >10 mg/mL

Disclaimer

Hygroscopic, photosensitive, and oxygen-sensitive. Solutions should be freshly prepared.

Biochem/physiol Actions

Potent, orally active D₁ dopamine receptor agonist.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

Manufactured and sold under exclusive license from Abbott Laboratories.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Comparison of interactions of D1-like agonists, SKF 81297, SKF 82958 and A-77636, with cocaine: locomotor activity and drug discrimination studies in rodents.

Allison L Chausmer et al.

Psychopharmacology, 159(2), 145-153 (2002-02-28)

Recent data suggest that dopamine (DA) D1-like receptor full agonists may be potential pharmacotherapeutic agents for treating cocaine abuse. The structurally novel isochroman D1-like agonist, A-77636, has not been well characterized and may prove to be useful as such an

Negative feedback regulation of nigrostriatal dopamine release: mediation by striatal D1 receptors.

Sanjida S Saklayen et al.

The Journal of pharmacology and experimental therapeutics, 311(1), 342-348 (2004-06-04)

The nigrostriatal dopamine system of the mammalian brain is necessary for normal voluntary motor activity. Dopamine exerts its effects by acting on two primary receptor subtypes: D1-like (D1 and D5) and D2-like (D2, D3, and D4) receptors. Previous research has

Neurobiology of executive functions: catecholamine influences on prefrontal cortical functions.

Amy F T Arnsten et al.

Biological psychiatry, 57(11), 1377-1384 (2005-06-14)

The prefrontal cortex guides behaviors, thoughts, and feelings using representational knowledge, i.e., working memory. These fundamental cognitive abilities subserve the so-called executive functions: the ability to inhibit inappropriate behaviors and thoughts, regulate our attention, monitor our actions, and plan and

Effects of YM 435 and A 77636 on dopamine D-1 receptors in bovine retina in vitro.

S Ofori et al.

General pharmacology, 26(1), 51-57 (1995-01-01)

1. Homogenates of bovine retinas were used to study the capacities of two new dopamine (DA) receptor agonists, e.g. YM 435 and A 77636, to interact with D1 receptors. 2. Adenylate cyclase experiments. YM 435 and A 77636 enhanced cAMP

Chronic lithium attenuates dopamine D1-receptor mediated increases in acetylcholine release in rat frontal cortex.

E Acquas et al.

Psychopharmacology, 125(2), 162-167 (1996-05-01)

The effects of chronic lithium treatment on methylphenidate-, D1 dopamine receptor agonist (A-77636)-, and tactile stimulation-induced increases in frontal cortical acetylcholine release were studied in the rat using in vivo brain microdialysis. Cortical acetylcholine release in control rats was maximally

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