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77739

Sigma-Aldrich

Pefachrome® Fxa

≥95.0% (HPLC)

Synonym(s):

N-Methoxycarbonyl-D-cyclohexylalanyl-glycyl-L-arginine-4-nitroanilide acetate, N-Methoxycarbonyl-D-Cha-Gly-Arg-4-nitroanilide acetate

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About This Item

Empirical Formula (Hill Notation):
C25H38N8O7 · C2H4O2
CAS Number:
80895-10-9
Molecular Weight:
622.67
MDL number:
MFCD03791099
UNSPSC Code:
12352200
PubChem Substance ID:
57652710

assay

≥95.0% (HPLC)

form

powder

solubility

water: 1 mg/mL, clear, colorless

suitability

degradable with trypsin for enzyme test (substrate for Factor Xa)

storage temp.

2-8°C

SMILES string

CC(O)=O.COC(=O)N[C@H](CC1CCCCC1)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)Nc2ccc(cc2)[N+]([O-])=O

InChI

1S/C25H38N8O7.C2H4O2/c1-40-25(37)32-20(14-16-6-3-2-4-7-16)22(35)29-15-21(34)31-19(8-5-13-28-24(26)27)23(36)30-17-9-11-18(12-10-17)33(38)39;1-2(3)4/h9-12,16,19-20H,2-8,13-15H2,1H3,(H,29,35)(H,30,36)(H,31,34)(H,32,37)(H4,26,27,28);1H3,(H,3,4)/t19-,20+;/m0./s1

InChI key

QXWRKXQCMBOLJR-CMXBXVFLSA-N

Application

Pefachrome® substrates are used for chromogenic assays of various serine proteinases. Pefachrome® Fxa is used for the detection of serine proteases such as blood coagulation factor Xa.

Packaging

1 piece contains 10 μmol Pefachrome® FXA

Legal Information

Pefachrome is a registered trademark of Pentapharm AG, Basel

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCBH9022V

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Marjory B Brooks
Veterinary clinical pathology, 33(4), 208-214 (2004-12-01)
Unfractionated heparin (UFH) has a complex pharmacologic profile that necessitates patient monitoring to prevent inadequate anticoagulation or overdosage and hemorrhage. Factor Xa inhibitory assays (to measure anti-Xa activity) are used to adjust UFH dosage and define safe and effective regimens
An optimised, rapid chromogenic assay, specific for measuring direct factor Xa inhibitors (rivaroxaban) in plasma.
Meyer Michel Samama et al.
Thrombosis and haemostasis, 104(5), 1078-1079 (2010-09-02)
Job Harenberg et al.
Journal of thrombosis and thrombolysis, 32(3), 267-271 (2011-08-04)
Rivaroxaban and other oral direct factor Xa inhibitors (ODiXa) are currently developed for prophylaxis and treatment of thromboembolic diseases using fixed doses. Although routine monitoring is not required, assessing the intensity of anticoagulation may be useful under certain clinical conditions.

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