91707

Trifluoroacetic acid

puriss. p.a., suitable for HPLC, ≥99.0% (GC)

• Synonym(s): TFA
• Linear Formula: CF₃COOH
• CAS Number: 76-05-1
• Molecular Weight: 114.02
• Beilstein/REAXYS Number: 742035
• EC Number: 200-929-3
• MDL number: MFCD00004169
• UNSPSC Code: 12352106
• PubChem Substance ID: 329770068
• NACRES: NA.21

Properties

• vapor density: 3.9 (vs air)
• Quality Level: 200
• vapor pressure: 97.5 mmHg ( 20 °C)
• grade: puriss. p.a.
• assay: ≥99.0% (GC)
• form: liquid
• technique(s): HPLC: suitable; LC/MS: suitable
• impurities: ≤0.05% water
• refractive index: n20/D 1.3 (lit.)
• pH: 1 (20 °C, 1 g/L)
• bp: 72.4 °C (lit.)
• mp: −15.4 °C (lit.)
• solubility: water: soluble
• density: 1.489 g/mL at 20 °C (lit.)
• λ: 1 cm path, H₂O reference
• UV absorption: λ: 260 nm A_max: 0.9; λ: 270 nm A_max: 0.1; λ: 280 nm A_max: 0.08; λ: 290 nm A_max: 0.07; λ: 300 nm A_max: 0.06; λ: 320 nm A_max: 0.05
• suitability: corresponds to standard for RP gradient test
• SMILES string: OC(C(F)(F)F)=O
• InChI: 1S/C2HF3O2/c3-2(4,5)1(6)7/h(H,6,7)
• InChI key: DTQVDTLACAAQTR-UHFFFAOYSA-N

Description

General description

Trifluoroacetic acid (TFA) is a fluorinated acetic acid. It is widely used as trifluoromethylating reagent for trifluoromethylation of aromatic compounds.

Application

Trifluoroacetic acid (TFA) may be used in the following studies:

• Preparation of TFA reagent for the estimation of serum vitamin A.
• To compose the binary solvent system for the isolation of large denatured peptides by reverse phase high performance liquid chromatography.
• A mobile-phase additive for liquid chromatography-mass spectrometry (LC-MS) analysis.
• Preparation of artemisinin under optimized reaction conditions.

Packaging

package with 10x1mL

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Safety Information

• pictograms: GHS05,GHS07
• signalword: Danger
• hcodes: H314,H332,H412
• pcodes: P261 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A
• Storage Class: 8A - Combustible corrosive hazardous materials
• wgk_germany: WGK 2
• flash_point_f: >212.0 °F - Pensky-Martens closed cup
• flash_point_c: > 100 °C - Pensky-Martens closed cup