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201154

Sigma-Aldrich

Sodium fluoride

ACS reagent, ≥99%

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About This Item

Linear Formula:
NaF
CAS Number:
7681-49-4
Molecular Weight:
41.99
EC Number:
231-667-8
MDL number:
MFCD00003524
UNSPSC Code:
12352302
PubChem Substance ID:
329751974
NACRES:
NA.21

grade

ACS reagent

Quality Level

200

agency

suitable for EPA 300

vapor pressure

1.4 mmHg ( 0 °C)

assay

≥99%

form

powder

impurities

≤0.01 meq/g Titr. base
≤0.02% insolubles
≤0.03 meq/g Titr. acid
≤0.1% sodium fluorosilicate

loss

≤0.3% loss on drying

mp

993 °C (lit.)

anion traces

chloride (Cl-): ≤0.005%
sulfate (SO42-): ≤0.03%
sulfite (SO32-): ≤0.005%

cation traces

Fe: ≤0.003%
K: ≤0.02%
heavy metals (as Pb): ≤0.003%

SMILES string

[F-].[Na+]

InChI

1S/FH.Na/h1H;/q;+1/p-1

InChI key

PUZPDOWCWNUUKD-UHFFFAOYSA-M

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General description

Sodium fluoride (NaF) is a metallic halide. It has been reported as dental caries preventive agent. It is the most widely employed chemical preservative for the preservation of glucose in blood. It has been reported to stabilize the hepatic microsomal glucose-6-P phosphohydrolase enzyme.

Application

Sodium fluoride may be employed as a fluorination agent in the synthesis of aromatic and aliphatic fluorides. It may be used to prepare the lysis buffer.
Sodium fluoride may be used as a fluorinating agent for chlorine-containing compounds via halogen-exchange reaction.
Starting material for solid state preparation of Na3MnF6 for further high pressure structural determination studies.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2

supp_hazards

EUH032

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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The effect on human dental caries of weekly oral rinsing with a sodium fluoride mouthwash: a final report.
Horowitz HS, et al.
Archives of Oral Biology, 16(6), 609-616 (1971)
A prospective, randomized clinical study on the effects of an amine fluoride/stannous fluoride toothpaste/mouthrinse on plaque, gingivitis and initial caries lesion development in orthodontic patients.
?gaard B, et al.
European Journal of Orthodontics, 28(1), 8-12 (2006)
J G Drachman et al.
The Journal of biological chemistry, 270(10), 4979-4982 (1995-03-10)
c-Mpl is a member of the cytokine receptor superfamily, expressed primarily on hematopoietic cells. Recently, the c-Mpl ligand was cloned and found to have thrombopoietic activity. In this paper we report that ligand binding induced tyrosine phosphorylation in BaF3 cells
Effectiveness of sodium fluoride as a preservative of glucose in blood.
Chan AY, et al.
Clinical Chemistry, 35(2), 315-317 (1989)
A J Lange et al.
The Journal of biological chemistry, 261(1), 101-107 (1986-01-05)
Stabilization and inhibition of hepatic microsomal glucose-6-P phosphohydrolase (EC 3.1.3.9) by F- requires the presence of Al3+ ions. At millimolar concentrations, reagent grade NaF inhibited glucose-6-P hydrolysis and protected the enzyme against inactivation induced by heat in the presence of
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