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T3812

Sigma-Aldrich

Tetracaine

meets USP testing specifications

Synonym(s):

4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester

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About This Item

Empirical Formula (Hill Notation):
C15H24N2O2
CAS Number:
94-24-6
Molecular Weight:
264.36
EC Number:
202-316-6
MDL number:
MFCD00053787
UNSPSC Code:
12352202
PubChem Substance ID:
24900174
NACRES:
NA.21

agency

USP/NF
meets USP testing specifications

Quality Level

200

application(s)

pharmaceutical (small molecule)

storage temp.

2-8°C

SMILES string

CCCCNc1ccc(cc1)C(=O)OCCN(C)C

InChI

1S/C15H24N2O2/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3/h6-9,16H,4-5,10-12H2,1-3H3

InChI key

GKCBAIGFKIBETG-UHFFFAOYSA-N

Gene Information

human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

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application

Topical ophthalmic anesthetic; used for spinal anesthesia

Biochem/physiol Actions

Blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2 - Skin Sens. 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
SLCR5764
0000256625
SLBZ8596
SLBQ5364V
SLBQ0104V

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Howard Bregman et al.
Journal of medicinal chemistry, 54(13), 4427-4445 (2011-06-04)
Clinical human genetic studies have recently identified the tetrodotoxin (TTX) sensitive neuronal voltage gated sodium channel Nav1.7 (SCN9A) as a critical mediator of pain sensitization. Herein, we report structure-activity relationships for a novel series of 2,4-diaminotriazines that inhibit hNav1.7. Optimization
Lotta Salmela et al.
International journal of pharmaceutics, 472(1-2), 276-281 (2014-06-20)
We present a continuous-flow method that allows the release of drugs from submicron colloidal carriers to be estimated on a millisecond timescale. The technique is applied to the study of release of a model drug (tetracaine) from lipid emulsions, and
Anna Taddio et al.
The Annals of pharmacotherapy, 36(4), 687-692 (2002-03-29)
To determine the relative efficacy of lidocaine-prilocaine and tetracaine for procedural pain in children. Systematic review was performed (MEDLINE1990-June 2001) of all studies comparing the efficacy of these 2 modalities of pain relief in children undergoing painful cutaneous procedures. Search
Ryan M Peters et al.
Journal of neurophysiology, 114(1), 264-273 (2015-05-01)
Galvanic vestibular stimulation (GVS) evokes a perception of rotation; however, very few quantitative data exist on the matter. We performed psychophysical experiments on virtual rotations experienced when binaural bipolar electrical stimulation is applied over the mastoids. We also performed analogous
Yveline Henchoz et al.
Journal of medicinal chemistry, 51(3), 396-399 (2008-01-15)
Accurate determinations of lipophilicity indices benefit from recent advances in chromatographic sciences such as the launch of ultraperformance liquid chromatography (UPLC). The fast strategy presented here emerges as a powerful method suitable for high-throughput log P measurements of therapeutic compounds
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