PHR1277

Nitrilotriacetic acid

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): Nitrilotriacetic acid, N,N-Bis(carboxymethyl)glycine, NTA, Tris(carboxymethyl)amine
• Linear Formula: N(CH₂COOH)₃
• CAS Number: 139-13-9
• Molecular Weight: 191.14
• Beilstein/REAXYS Number: 1710776
• EC Number: 205-355-7
• MDL number: MFCD00004287
• UNSPSC Code: 41116107
• PubChem Substance ID: 329823273
• NACRES: NA.24

Properties

• grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• agency: traceable to USP 1463950
• API family: edta
• CofA: current certificate can be downloaded
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• mp: 245 °C (dec.) (lit.)
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-8°C
• SMILES string: OC(=O)CN(CC(O)=O)CC(O)=O
• InChI: 1S/C6H9NO6/c8-4(9)1-7(2-5(10)11)3-6(12)13/h1-3H2,(H,8,9)(H,10,11)(H,12,13)
• InChI key: MGFYIUFZLHCRTH-UHFFFAOYSA-N

Description

General description

Nitrilotriacetic acid (NTA) is a polyaminopolycarboxylic acid, widely used as a synthetic chelating agent. It forms stable and water-soluble chelates with different metals. It is used as a detergent builder to soften water and for masking metal ions in various industrial processes.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

An excellent chelating agent.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3702 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Safety Information

• pictograms: GHS08,GHS07
• signalword: Warning
• hcodes: H302,H319,H351
• pcodes: P202 - P264 - P280 - P301 + P312 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: 212.0 °F - closed cup
• flash_point_c: 100 °C - closed cup