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P5631

Sigma-Aldrich

o-Cresolphthalein Complexone

powder

Synonym(s):

o-Cresolphthalein-3′,3′′-bis-methyleneiminodiacetic acid, o-Cresolphthalexon, Metal phthalein, Phthalein purple, Xylenylphthalein-bisiminodiacetic acid

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1 G
$33.60
5 G
$108.00
10 G
$213.00
25 G
$408.00
100 G
$1,180.00

$33.60

Estimated to ship onMay 30, 2025

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All Photos(7)

Select a Size

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1 G
$33.60
5 G
$108.00
10 G
$213.00
25 G
$408.00
100 G
$1,180.00

About This Item

Empirical Formula (Hill Notation):
C32H32N2O12
CAS Number:
2411-89-4
Molecular Weight:
636.60
Beilstein/REAXYS Number:
381994
EC Number:
219-318-8
MDL number:
MFCD00005911
UNSPSC Code:
12171500
PubChem Substance ID:
24898682
NACRES:
NA.47

$33.60

Estimated to ship onMay 30, 2025

Request a Bulk Order

form

powder

Quality Level

200

technique(s)

titration: suitable

color

white to off-white

mp

181-185 °C (dec.) (lit.)

solubility

methanol: 1 mg/mL

suitability

suitable for determination of calcium

application(s)

diagnostic assay manufacturing
hematology
histology

Storage temp.

room temp

SMILES string

Cc1cc(cc(CN(CC(O)=O)CC(O)=O)c1O)C2(OC(=O)c3ccccc23)c4cc(C)c(O)c(CN(CC(O)=O)CC(O)=O)c4

InChI

1S/C32H32N2O12/c1-17-7-21(9-19(29(17)43)11-33(13-25(35)36)14-26(37)38)32(24-6-4-3-5-23(24)31(45)46-32)22-8-18(2)30(44)20(10-22)12-34(15-27(39)40)16-28(41)42/h3-10,43-44H,11-16H2,1-2H3,(H,35,36)(H,37,38)(H,39,40)(H,41,42)

Inchi Key

IYZPEGVSBUNMBE-UHFFFAOYSA-N

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General description

o-Cresolphthalein Complexone is a pH indicator dye commonly used for the calorimetric determination of calcium in serum.

Application

o-Cresolphthalein Complexone has been used in the estimation of calcium in serum samples based on the reaction of Ca2+ with o-cresolphthalein complexone in an alkaline solution.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF5504V
SDBB1982
0000428376
0000428376
WXBF4960V

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C M Corns et al.
Annals of clinical biochemistry, 24 ( Pt 4), 345-351 (1987-07-01)
The reasons for the non-linearity of the standard curve for the calcium-cresolphthalein complexone reaction have been investigated. Calcium forms both 1:1 and 2:1 complexes with cresolphthalein complexone; at low calcium concentrations the 1:1 complex predominates and causes non-linearity. At high
J Toffaletti et al.
Clinical chemistry, 26(11), 1562-1565 (1980-10-01)
We adapted a method for dialyzable calcium from fluorometric detection by use of calcein to a more specific spectrophotometric determination with cresolphthalein complexone. The reagents are available commercially and perform satisfactorily with respect to noise level, drift, stability, and sensitivity.
M A Koupparis et al.
Clinical chemistry, 28(10), 2149-2152 (1982-10-01)
We describe the measurement of total calcium and magnesium in serum with an automated microcomputer-controlled stopped-flow analyzer. The calcium method is based on the cresolphthalein complexone procedure, with 2-amino-3-methyl-1-propanol as the alkalinizing agent. The assay, performed on 60-fold prediluted samples
R J Liedtke et al.
Clinical chemistry, 27(12), 2025-2028 (1981-12-01)
We describe an automated method for calcium assay, for use with the Cobas-Bio centrifugal analyzer. Calcium is reacted with cresolphthalein complexone and the absorbance of the calcium--dye complex at 575 nm is measured. EDTA is then added to break up
Sandra F Williams et al.
Mayo Clinic proceedings, 80(12), 1655-1657 (2005-12-14)
Severe hypocalcemia may require prompt intervention to avoid life-threatening consequences. We report a case in which a 78-year-old man had a critically low serum calcium level measured with use of standard colorimetric assay after gadodiamide administration during magnetic resonance angiography.
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