K2012

Ketoprofen

Name: Ketoprofen
Brand: SIAL

meets USP testing specifications

Synonym(s):

2-(3-Benzoylphenyl)propionic acid

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₄O₃

CAS Number:

22071-15-4

Molecular Weight:

254.28

NACRES:

NA.21

PubChem Substance ID:

24896217

UNSPSC Code:

41116107

EC Number:

244-759-8

MDL number:

MFCD00055790

Key Documents

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Quality Level

200

agency

USP/NF, meets USP testing specifications

form

solid

application(s)

pharmaceutical (small molecule)

SMILES string

CC(C(O)=O)c1cccc(c1)C(=O)c2ccccc2

InChI

1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)

InChI key

DKYWVDODHFEZIM-UHFFFAOYSA-N

Gene Information

human ... ALB(213), IL8RA(3577), PTGS1(5742), PTGS2(5743)

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Show Differences

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This Item	K1751	I7905	A3160
Sigma-Aldrich K2012 Ketoprofen	Sigma-Aldrich K1751 Ketoprofen	Sigma-Aldrich I7905 Ibuprofen	Sigma-Aldrich A3160 Acetylsalicylic acid
Gene Information human ... ALB(213), IL8RA(3577), PTGS1(5742), PTGS2(5743)	Gene Information human ... ALB(213), IL8RA(3577), PTGS1(5742), PTGS2(5743)	Gene Information human ... ALB(213), ALOX5(240), CYP1A2(1544), CYP2C9(1559), IL8RA(3577), PTGS1(5742), PTGS2(5743) mouse ... Alox5(11689) rat ... Alox5(25290), Ptgs1(24693)	Gene Information human ... ITGA2B(3674), PTGS1(5742), PTGS2(5743)
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
form solid	form powder	form solid	form powder
agency USP/NF	agency -	agency USP/NF, meets USP testing specifications	agency -
application(s) pharmaceutical (small molecule)	application(s) -	application(s) pharmaceutical (small molecule)	application(s) forensics and toxicology pharmaceutical veterinary

Application

A strong, silk protein-inspired tissue adhesive with an enhanced drug release mechanism for transdermal drug delivery.: Although not exclusively focused on ketoprofen, this study details a novel adhesive for transdermal delivery, highlighting methods that could be adapted for enhancing the delivery of ketoprofen, thus being of interest to biochemists specializing in transdermal drug formulations (Fang et al., 2024).

Biochem/physiol Actions

Non-steroidal anti-inflammatory compound that is selective for COX-1.

pictograms

GHS06,GHS09

signalword

Danger

hcodes

H301,H315,H319,H400

pcodes

P264 - P273 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number

0000493735

0000333416

0000333417

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Identification of a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with favorable physicochemical and in vitro ADME properties.

Elisabeth Christiansen et al.

Journal of medicinal chemistry, 54(19), 6691-6703 (2011-08-23)

The free fatty acid receptor 1 (FFA1, also known as GPR40) enhances glucose-stimulated insulin secretion from pancreatic β-cells and is recognized as an interesting new target for treatment of type 2 diabetes. Several series of selective FFA1 agonists are already

Continuous-flow encapsulation of ketoprofen in copolymer microbeads via co-axial microfluidic device: influence of operating and material parameters on drug carrier properties.

Ikram Ullah Khan et al.

International journal of pharmaceutics, 441(1-2), 809-817 (2012-12-26)

Microchannels based microfluidic systems are able to obtain monodispersed microparticles but are limited by cost, time and channel clogging. We succeeded in on the fly encapsulation of high ketoprofen contents in acrylate-based copolymer microbeads by environment friendly UV induced free

The effect of administering ketoprofen on the physiology and behavior of dairy cows following surgery to correct a left displaced abomasum.

Nathalie C Newby et al.

Journal of dairy science, 96(3), 1511-1520 (2013-01-22)

Surgical correction of left displaced abomasum (LDA) is common in lactating dairy cattle. Despite the growing acceptance that abdominal surgery is painful, few cows are administered analgesia following LDA surgery. The objective of this research was to examine the effect

Clinical pharmacokinetics of ketoprofen and its enantiomers.

F Jamali et al.

Clinical pharmacokinetics, 19(3), 197-217 (1990-09-01)

Ketoprofen, a potent nonsteroidal anti-inflammatory drug (NSAID) of the 2-arylpropionic acid class, has been used clinically for over 15 years in Europe, and has recently been introduced in the United States. Although it possesses a chiral centre, with only the

4 cases of photocontact dermatitis due to ketoprofen.

M Sugiura et al.

Contact dermatitis, 43(1), 16-19 (2000-07-21)

We report 4 cases of photocontact dermatitis due to ketoprofen, a non-steroidal anti-inflammatory drug derived from propionic acid. We carried out a skin biopsy to examine the amount of ketoprofen in the eruptive skin. We investigated the cross-reactions between tiaprofenic

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Global Trade Item Number

SKU	GTIN
K2012-5G	04061833868270
K2012-25G	04061833868263

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