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C0414

Supelco

Clidinium bromide

analytical standard

Synonym(s):

3-Hydroxy-1-methylquinuclidinium bromide benzilate, 3-[(Hydroxydiphenylacetyl)oxy]-1-methyl-1-azoniabicyclo[2.2.2]octane bromide

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1 G
$91.40

$91.40

Estimated to ship onMay 31, 2025

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1 G
$91.40

About This Item

Empirical Formula (Hill Notation):
C22H26BrNO3
CAS Number:
3485-62-9
Molecular Weight:
432.35
EC Number:
222-471-3
MDL number:
MFCD00078996
UNSPSC Code:
41116107
PubChem Substance ID:
329774786
NACRES:
NA.24

$91.40

Estimated to ship onMay 31, 2025

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grade

analytical standard

Quality Level

200

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

Br.C[N]12CCC(CC1)C(C2)OC(=O)C(O)(c3ccccc3)c4ccccc4

InChI

1S/C22H26NO3.BrH/c1-23-14-12-17(13-15-23)20(16-23)26-21(24)22(25,18-8-4-2-5-9-18)19-10-6-3-7-11-19;/h2-11,17,20,25H,12-16H2,1H3;1H

InChI key

WVDSMJSQJXGCNY-UHFFFAOYSA-N

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General description

Clidinium bromide is an anticholinergic, antisecretory and antispasmodic drug, widely used in treating anxiety-related conditions and spastic colon by inhibiting the action of parasympathetic innervations thus decreasing the secretions of stomach acid and slowing the intestines.[1][2]

Application

Clidinium bromide has been used as an analytical standard for the quantification of the analyte in pharmaceutical formulations[3][1][2] using different analytical techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

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Simultaneous determination of chlordiazepoxide and clidinium bromide in pharmaceutical formulations by derivative spectrophotometry
Toral I.M, et al.
The Veterinary Quarterly, 189(1), 67-74 (1999)
H Valette et al.
European journal of pharmacology, 306(1-3), 133-138 (1996-06-13)
The muscarinic receptor antagonist methyl-quinuclidinyl-benzylate decreased myocardial beta-adrenoceptor density Bmax: 20.4 +/- 2.4 pmol/ml tissue versus 33.3 +/- 4 pmol/ml tissue in control dogs (P < 0.001), as assessed by using [11C]CGP-12177 (((2S)-4-(3-t-butyl-amino-2 hydroxypropoxy)-benzimidazol-2-one)) and positron emission tomography. In contrast
F Brunner et al.
British journal of pharmacology, 102(2), 373-380 (1991-02-01)
1. Muscarinic receptors on endothelial cells of bovine thoracic aorta were characterized by binding assays in which (-)-[3H]-N-methyl quinuclidinyl benzilate ([3H]-NMeQNB) was used as radioligand. 2. Binding of [3H]-NMeQNB to crude membranes of freshly isolated endothelial cells was atropine-displaceable and
E Malatynska et al.
Brain research bulletin, 47(3), 285-290 (1998-12-29)
Three chimeric receptors stably expressed in murine fibroblast (B82) cells were used to examine how different parts of the rat muscarinic m1 and m2 receptors contribute to the down-regulation process. The MCH7 chimeric m2 receptor contained a fragment between VIth
J Delforge et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 34(6), 981-991 (1993-06-01)
The potential for noninvasive quantification of myocardial muscarinic receptors using PET data, a mathematical model, multi-injection protocols and 11C-labeled methylquinuclidinyl benzilate (MQNB) as a radioligand was previously demonstrated in dogs. The present study examines the possibility of optimizing the experimental
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