85992
N-(N-Succinyl-L-phenylalanyl)-2-aminoacridone
for fluorescence, ≥98.0% (HPCE)
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About This Item
Empirical Formula (Hill Notation):
C26H23N3O5
CAS Number:
Molecular Weight:
457.48
MDL number:
UNSPSC Code:
12352200
Recommended Products
grade
for fluorescence
assay
≥98.0% (HPCE)
mp
249-253 °C (lit.)
solubility
DMF: soluble
DMSO: soluble
H2O: soluble
fluorescence
λex 398 nm; λem 440 nm in 0.1 M Tris pH 8.0 (fluoroescence decreases upon cleavage with α-chymotrypsin)
storage temp.
2-8°C
SMILES string
OC(=O)CCC(=O)N[C@@H](Cc1ccccc1)C(=O)Nc2ccc3Nc4ccccc4C(=O)c3c2
Application
suitable as photometric substrate for α-chymotrypsin (linear increase in absorbance at 450 nm)
Analysis Note
In addition to the emission maximum at 440 nm, there is a lower maxima at 463 nm.
Other Notes
Substrate for the continuous assay of α-chymotrypsin at wavelengths 450/570nm[1]
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J H Baustert et al.
Analytical biochemistry, 171(2), 393-397 (1988-06-01)
A direct and continuous kinetic method for the fluorometric determination of alpha-chymotrypsin and trypsin is described, and 2-aminoacridone (2-AA) is introduced as a promising new fluorophore in analytical biochemistry. N-Succinyl- and N-glutaryl-phenylalanine as well as N-benzoylarginine were coupled to 2-AA
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