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61767

Sigma-Aldrich

Lectin from Triticum vulgaris

lyophilized, ≥55% (GE), powder

Synonym(s):

WGA, Wheat germ agglutinin

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5 MG
$116.00

$116.00

Available to ship onApril 08, 2025Details

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5 MG
$116.00

About This Item

MDL number:
MFCD00147408
UNSPSC Code:
12352202
NACRES:
NA.56

$116.00

Available to ship onApril 08, 2025Details

biological source

Triticum vulgaris

form

powder

quality

lyophilized

concentration

≥55% (GE)

technique(s)

agglutination assay: suitable using fresh human erythrocytes

storage temp.

2-8°C

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General description

Lectins are carbohydrate-binding proteins, omnipresent, found in fungi, plants and animals. The structure of lectin is diversely studied in plants and animals. The secondary structure of this protein is rich in β-strands and posses a carbohydrate binding sites on the surface.[1]
WGA is not blood group specific but has an affinity for N-acetyl-β-D-glucosaminyl residues and N-acetyl-β-D-glucosamine oligomers. WGA contains no protein-bound carbohydrate.[2]

Application

Lectin from Triticum vulgaris has been used in bone resorption assays.[3]
Wheat germ agglutinin conjugated to the outside surface of PLGA nanoparticles loaded with paclitaxel was used to target cancer cells that overexpress WGA-binding glycoproteins (Caco-2 and HT-29 cell lines). WGA-NP showed 50-60% greater endocytosis and intracellular retention of paclitaxel than unlabeled nanoparticles.[4]

Biochem/physiol Actions

Lectin is known to be useful in glycoconjugate characterizing, imaging and targeting. Its use in a microarray assay, enable efficient glycome profiling. This is because of its specific interaction with oligosaccharides, glycoproteins and glycolipids. In plants and fungi, lectin defends against pathogens/feeders. Lectin participates in host recognition and tissue adhesion, thereby aids in the pathogenesis of microorganism.[1]

Other Notes

Molecular characteristics and specificity for sugar binding[2]

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCK4817
BCCH6903
BCCC8266
BCBZ6176
BCBW2381

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Alternative NF-kB Regulates RANKL-Induced Osteoclast Differentiation and Mitochondrial Biogenesis via Independent Mechanisms
Zeng R, et al.
Journal of Bone and Mineral Research, 30(12), 2287-2299 (2015)
Chunxia Wang et al.
International journal of pharmaceutics, 400(1-2), 201-210 (2010-09-02)
The purpose of this study was to investigate the potentiation of the anticancer activity and enhanced cellular retention of paclitaxel-loaded PLGA nanoparticles after surface conjugation with wheat germ agglutinin (WGA) against colon cancer cells. Glycosylation patterns of representative colon cancer
Yinglong Zhao et al.
Frontiers in cell and developmental biology, 9, 796902-796902 (2022-02-22)
Microgravity prominently affected cardiovascular health, which was the gravity-dependent physical factor. Deep space exploration had been increasing in frequency, but heart function was susceptible to conspicuous damage and cardiac mass declined in weightlessness. Understanding of the etiology of cardiac atrophy
Wheat germ agglutinin. Molecular characteristics and specificity for sugar binding.
Y Nagata et al.
The Journal of biological chemistry, 249(10), 3116-3122 (1974-05-25)
Binding sugars: from natural lectins to synthetic receptors and engineered neolectins
Arnaud J, et al.
Chemical Society Reviews, 42(11), 4798-4813 (2013)
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Lectin Selection Guide: A Useful Guide for Selecting the Right Lectin

Find the right lectin for your research with our lectin selection guide, organized by lectin source/species, carbohydrate specificity, blood group specificity, and more.

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