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Sigma-Aldrich

1,4-Diaminobutane dihydrochloride

purum, ≥99.0% (AT)

Synonym(s):

Putrescine dihydrochloride, 1,4-Butanediamine dihydrochloride, 1,4-Diaminobutane dihydrochloride, Tetramethylenediamine dihydrochloride

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About This Item

Linear Formula:
NH2(CH2)4NH2 · 2HCl
CAS Number:
333-93-7
Molecular Weight:
161.07
Beilstein/REAXYS Number:
3906680
EC Number:
206-375-9
MDL number:
MFCD00012526
UNSPSC Code:
12352116
PubChem Substance ID:
329754336
NACRES:
NA.22

grade

purum

Quality Level

400

assay

≥99.0% (AT)

form

powder

mp

280 °C (dec.) (lit.)

solubility

water: soluble 1 g/10 mL, clear, colorless

SMILES string

Cl[H].Cl[H].NCCCCN

InChI

1S/C4H12N2.2ClH/c5-3-1-2-4-6;;/h1-6H2;2*1H

InChI key

XXWCODXIQWIHQN-UHFFFAOYSA-N

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Application

  • Nanocomposite PLA/C20A nanoclay by ultrasound-assisted melt extrusion for adsorption of uremic toxins and methylene blue dye: This study explored the modification of nanoclay with 1,4-diaminobutane dihydrochloride for adsorptive applications, showing enhanced performance in toxin removal (Andrade-Guel et al., 2021).
  • The Total Synthesis of Spermine Alkaloid Kukoamine Bimesylate: This paper details the synthetic route of spermine alkaloid derivatives using 1,4-diaminobutane dihydrochloride, highlighting methods applicable in medicinal chemistry (Dong, 2018).

Biochem/physiol Actions

Binds to the polyamine modulatory site of the NMDA receptor and potentiates NMDA-induced currents; precursor of spermidine.

pictograms

Skull and crossbonesCorrosion
GHS06,GHS05

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 1

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL8316
BCCK1424
BCCJ7143
BCCL3845
BCCJ7144

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Henning Jørgensen et al.
Analytical biochemistry, 317(1), 85-93 (2003-05-06)
Cellulases and hemicellulases are two classes of enzymes produced by filamentous fungi and secreted into the cultivation medium. Both classes of enzymes consist of a subset of classes of which the fungi produce several enzymes with varying molecular mass and
Alkylammonium Hexachlorometallates, IV. Synthesis and Crystal Structure of Bis (1, 4-diammoniobutane) Diaquahydrogen Hexachlororhodate (III) Dichloride,[H3N-(CH2) 4-NH3] 2 [H5O2][RhCl6] Cl2.
Frank W and Rei? GJ.
Chemische Berichte, 129(11), 1355-1359 (1996)
J Kirschbaum et al.
Journal of chromatography. A, 881(1-2), 517-530 (2000-07-25)
The reagent 3,5-dinitrobenzoyl chloride (DNBZ-Cl) was tested for pre-column derivatization of biogenic amines (BAs). Samples were derivatized within 3 min in 1 M NaOH at ambient temperature by adding 2-propanole and 50 mM DNBZ-Cl in acetonitrile. The reaction was terminated
Valeria M Nurchi et al.
Journal of inorganic biochemistry, 194, 26-33 (2019-02-27)
A comprehensive study of the protonation equilibria of a series of polyamine ligands along with their complex formation equilibria with Cu2+ and Zn2+ is reported in this work. The primary aim of this study has been the achievement of homogeneous
Anna Czajkowska-Mysłek et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 105, 82-92 (2017-04-04)
Potential adverse reactions among infants and young children could appear after consumption of food containing small amounts of bioactive amines. This study presents the first assessment of biogenic amines occurrence in ready-to-eat vegetable without/with fish, meat and fruit baby products
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