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Supelco

Hypaconitine

analytical standard

Synonym(s):

16,16-trimethoxy-4-(methoxymethyl)-20-methyl-,8-acetate benzoate,(1-α,6-α,14-α,15-α,16-β)-aconitane-8,13,14,15-tetraol

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About This Item

Empirical Formula (Hill Notation):
C33H45NO10
CAS Number:
6900-87-4
Molecular Weight:
615.71
UNSPSC Code:
12352200
NACRES:
NA.24

grade

analytical standard

assay

≥97.5% (HPLC)

optical activity

[α]/D 22.5±2.5°, c = 0.1 in chloroform

shelf life

limited shelf life, expiry date on the label

format

neat

storage temp.

2-8°C

SMILES string

O=C(C1=CC=CC=C1)O[C@H]2[C@@]3(O)[C@@H](OC)[C@H](O)[C@]4(OC(C)=O)C5[C@H](OC)C6C([C@@H](OC)CC[C@]6(CN7C)COC)(C75)[C@H](C3)C42

InChI

1S/C33H45NO10/c1-17(35)44-33-21-19(14-31(38,28(42-6)26(33)36)27(21)43-29(37)18-10-8-7-9-11-18)32-20(40-4)12-13-30(16-39-3)15-34(2)25(32)22(33)23(41-5)24(30)32/h7-11,19-28,36,38H,12-16H2,1-6H3/t19-,20+,21?,22?,23+,24?,25?,26+,27-,28+,30+,31-,32?,33-/m1/s1

InChI key

FIDOCHXHMJHKRW-XCIBRDTCSA-N

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General description

Hypaconitine is a constituent of diester-diterpene Aconitum alkaloids (AAs), which are found in aconite plants.

Application

Hypaconitine may be used as an analytical standard for the determination of the analyte in biological samples, Aconitum tubers by liquid chromatography (LC) based techniques.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCBZ6608
BCBW6149
BCBR8710
26599973
74464276

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Simultaneous analysis of aconitine, mesaconitine, hypaconitine, and jesaconitine in whole blood by LC-MS-MS using a new polymer column
Hattori H, et al.
Forensic Toxicology, 27(1), 7-11 (2009)
Lei-ping He et al.
Journal of analytical toxicology, 33(9), 588-594 (2009-12-31)
A rapid, sensitive, and specific liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS-MS) method was developed and validated for simultaneous determination of aconitine (AC), mesaconitine (MA), and hypaconitine (HA), the three toxic constituents from Sini decoction (SND) in rat plasma. After the
Simultaneous quantitation of aconitine, mesaconitine, hypaconitine, benzoylaconine, benzoylmesaconine and benzoylhypaconine in human plasma by liquid chromatography-tandem mass spectrometry and pharmacokinetics evaluation of ?SHEN-FU? injectable powder
Zhang F, et al.
Journal of Chromatography. B, Biomedical Applications, 873(2), 173-179 (2008)
Bo Sun et al.
Analytical biochemistry, 395(2), 125-133 (2009-08-18)
The Aconitum alkaloids aconitine, mesaconitine, and hypaconitine are the main toxic components in a commonly used traditional Chinese herbal medicine Fu Zi. To provide guidelines for the safe use of this medicine, metabolic changes in Wistar rats caused by these
Rina Kaneko et al.
Journal of mass spectrometry : JMS, 41(6), 810-814 (2006-06-14)
The Aconitum species (Ranunculaceae) are widely distributed in northern Asia and North America. Their roots are popularly used in herbal medicines in China and Japan. Many cases of accidental, suicidal and homicidal intoxication with this plant have been reported; some
View All Related Papers

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