12806

O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate

≥97.0% (N), for peptide synthesis

• Synonym(s): N,N,N′,N′-Tetramethyl-O-(benzotriazol-1-yl)uronium tetrafluoroborate, TBTU
• Linear Formula: C₁₁H₁₆N₅O · BF₄
• CAS Number: 125700-67-6
• Molecular Weight: 321.08
• Beilstein/REAXYS Number: 7066325
• MDL number: MFCD00077413
• UNSPSC Code: 12352100
• PubChem Substance ID: 329749883
• NACRES: NA.21

Properties

• product name: O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate, ≥97.0% (N)
• Quality Level: 200
• assay: ≥97.0% (N)
• form: solid
• mp: 205 °C (dec.) (lit.)
• solubility: acetonitrile: 0.1 g/mL, clear, colorless
• application(s): peptide synthesis
• storage temp.: 2-8°C
• SMILES string: F[B-](F)(F)F.CN(C)\C(On1nnc2ccccc12)=[N+](/C)C
• InChI: 1S/C11H16N5O.BF4/c1-14(2)11(15(3)4)17-16-10-8-6-5-7-9(10)12-13-16;2-1(3,4)5/h5-8H,1-4H3;/q+1;-1
• InChI key: JKEKMBGUVUKMQB-UHFFFAOYSA-N

Description

Application

Coupling reagent which is ideally suited for solid-phase peptide synthesis.

Other Notes

Recent studies show that crystal as well as solution structure of this coupling agent is a guanidinium N-oxide and not an uronium compound; Coupling reagent which is ideally suited for solid-phase peptide synthesis.

Safety Information

• pictograms: GHS02,GHS07
• signalword: Danger
• hcodes: H228,H317
• pcodes: P210 - P240 - P241 - P261 - P280 - P302 + P352
• Hazard Classifications: Flam. Sol. 1 - Skin Sens. 1A
• Storage Class: 4.1A - Other explosive hazardous materials
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves