00140585

Isoquercitrin

primary reference standard

• Synonym(s): Quercetin 3-β-D-glucoside, 3,3′,4′,5,7-Pentahydroxyflavone 3-β-glucoside, Isoquercitrin
• Empirical Formula (Hill Notation): C₂₁H₂₀O₁₂
• CAS Number: 482-35-9
• Molecular Weight: 464.38
• Beilstein/REAXYS Number: 100989
• MDL number: MFCD00017746
• UNSPSC Code: 85151701
• PubChem Substance ID: 329747007
• NACRES: NA.24

Properties

• grade: primary reference standard
• shelf life: limited shelf life, expiry date on the label
• manufacturer/tradename: HWI
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• SMILES string: OC[C@H]1O[C@@H](OC2=C(Oc3cc(O)cc(O)c3C2=O)c4ccc(O)c(O)c4)[C@H](O)[C@@H](O)[C@@H]1O
• InChI: 1S/C21H20O12/c22-6-13-15(27)17(29)18(30)21(32-13)33-20-16(28)14-11(26)4-8(23)5-12(14)31-19(20)7-1-2-9(24)10(25)3-7/h1-5,13,15,17-18,21-27,29-30H,6H2/t13-,15-,17+,18-,21+/m1/s1
• InChI key: OVSQVDMCBVZWGM-QSOFNFLRSA-N

Description

General description

Isoquercitrin is a flavonoid, glucoside derivative of quercitrin, and protein disulfide isomerase (PDI) inhibitor. Obtained from the leaf of medicinal plants, such as Apocynum venetum among others, it is known for its anti-oxidant and anti-thrombotic activities.

Produced and qualified by HWI pharma services GmbH.
Exact content measured by quantitative NMR can be found on the certificate.

Application

The primary reference standard can be used for identification, assay, and purity testing, method development, and validation.It can also be used as follows:

• Development of a synergistic cloud point extraction (SCPE) method for the extraction of isoquercitrin in rat plasma samples and its subsequent analysis by high-performance liquid chromatography (HPLC)
• Electrochemical analysis of isoquercitrin and epigallocatechin gallate by cyclic voltammetry using carbon nanotubes based electrode
• Simultaneous determination of rutin and isoquercitrin by differential pulse voltammetry (DPV) using glassy carbon electrode (GCE) modified with deposition of thio-β-cyclodextrin functionalized graphene/palladium nanoparticles (SH-β-CD-Gr/PdNPs) for pharmaceutical and medical analysis
• Multi-residue analysis of isoquercitrin, campesterol, emodin 8-O-β-D-glucopyranoside, and quercetin in dried stem and flower extracts of Reynoutria sachalinensis by high-performance liquid chromatography coupled with diode-array detection

Other Notes

This compound is commonly found in plants of the genus: arnica sambucus

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3