Recommended Products
assay
≥98% (HPLC)
form
lyophilized
mol wt
calculated mol wt 266.38
packaging
pkg of 1 mg
manufacturer/tradename
Millipore
storage condition
desiccated
protect from light
technique(s)
cell based assay: suitable
color
yellow
detection method
fluorometric
shipped in
ambient
storage temp.
−20°C
General description
Monoamine oxidases (MAOs) are important enzymes that catalyze the transformation of various neurotransmitters including serotonin, dopamine, and phenethylamine. They have two functionally distinct but structurally similar isoforms (MAO-A and MAO-B). The ability to differentiate the isoforms by using fluorescence detection/imaging technology is biologically relevant, but challenging with currently available chemical tools.
BioTracker Red MAO-A Live Cell Dye is a specific two-photon fluorogenic probe for detecting and visualizing MAO-A activity. This probe may be used to detect MAO-A enzymatic activities in various biological samples, including live mammalian cells, mouse and human tissues by using two-photon fluorescence microscopy with minimal cytotoxicity.
Reference:
1. Fang, H., Zhang, H., Li, L., Ni, Y., Shi, R., Li, Z., ... & Huang, W. (2020). Rational Design of a Two?Photon Fluorogenic Probe for Visualizing Monoamine Oxidase A Activity in Human Glioma Tissues. Angewandte Chemie, 132(19), 7606-7611.
BioTracker Red MAO-A Live Cell Dye is a specific two-photon fluorogenic probe for detecting and visualizing MAO-A activity. This probe may be used to detect MAO-A enzymatic activities in various biological samples, including live mammalian cells, mouse and human tissues by using two-photon fluorescence microscopy with minimal cytotoxicity.
Reference:
1. Fang, H., Zhang, H., Li, L., Ni, Y., Shi, R., Li, Z., ... & Huang, W. (2020). Rational Design of a Two?Photon Fluorogenic Probe for Visualizing Monoamine Oxidase A Activity in Human Glioma Tissues. Angewandte Chemie, 132(19), 7606-7611.
Application
Purity ≥ 98% confirmed by HPLC. Identification confirmed by HNMR, LC-MS, and elemental analysis.
Features and Benefits
Specific two-photon fluorogenic probe for detecting and visualizing MAO-A activity in live cells, mouse and human tissues.
Physical form
Lyophilized. Yellow solid.
Storage and Stability
Store at -20°C, desiccate and protect from light
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening
Other Notes
Live cell fluorescent imaging
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Haixiao Fang et al.
Angewandte Chemie (International ed. in English), 59(19), 7536-7541 (2020-02-23)
Monoamine oxidases have two functionally distinct but structurally similar isoforms (MAO-A and MAO-B). The ability to differentiate them by using fluorescence detection/imaging technology is of significant biological relevance, but highly challenging with available chemical tools. Herein, we report the first
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