The PDE4D Inhibitor, GEBR-7b controls the biological activity of PDE4D. This small molecule/inhibitor is primarily used for Cell Signaling applications.
A cell permeable, potent, and selective oxime PDE4D inhibitor (IC50 = 0.67 µM) which displays much reduced activities toward other PDE4 isoforms. It is shown to cause a significant 40% increase in extracellular cAMP in the hippocampus of freely moving rats in vivo at 100 µM, but has no effect on Aβ levels. This compound elicits cognitive enhancement in vivo at the optimum dose of 0.003 mg/kg in both mice and rat models, and unlike rolipram, does not cause emesis-like behavior in rodents.
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Other Notes
Bruno, O., et al. 2011. Br. J. Pharmacol.in press. Bruno, O., et al. 2009. J. Med. Chem.52, 6546.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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