A highly selective and potent agonist for recombinant human mGlu2 and mGlu3 receptors (Ki = 149 nM and 92 nM, respectively) and for rat neurons mGlu2/3 receptors (Ki = 88 nM). Negligible interactions with other mGlu receptors and ionotropic glutamate receptors, glutamate transporter subtypes, monoamine and other receptors. Widely used for investigating neuropsychiatric disorders in animal models and developing potential treatment for human mental disorders, such as schizophrenia.
Biochem/physiol Actions
Primary Target mGlu₂ & mGlu₃
Target Ki: 149 nM and 92 nM for human mGlu₂ and mGlu₃, respectively.
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months ta -20°C.
Other Notes
Seeman, P., 2013. Neuropharmacology.66, 87. Rorick-Kehn, L., et al. 2007. J. Pharmacol. Exp. Ther.321, 308. Fell, M., et al. 2008. J. Pharmacol. Exp. Ther.326, 209. Rodd, Z., et al. 2006. Behav. Brain Res.171, 207. Mezler, M., et al. 2010. Curr. Opi. In Investigational Drugs.11, 833.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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