219457

Cdk Inhibitor, p35 - CAS 471270-60-7 - Calbiochem

• Synonym(s): Cdk Inhibitor, p35 - CAS 471270-60-7 - Calbiochem, 2-(3-Hydroxypropylamino)-6-( o-hydroxybenzylamino)-9-isopropylpurine
• Empirical Formula (Hill Notation): C₁₈H₂₄N₆O₂
• CAS Number: 471270-60-7
• Molecular Weight: 356.42
• UNSPSC Code: 12352200

Properties

• assay: ≥95% (HPLC)
• Quality Level: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: yellow
• solubility: DMSO: 10 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Description

General description

This product has been discontinued.

An analog of Olomoucine (Cat. No. 495620) that acts as a potent inhibitor of Cdk1 (IC₅₀ = 100 nM) and Cdk2 (IC₅₀ = 80 nM). Also displays anti-proliferative and pro-apoptotic effects. The correlation between inhibition of Cdk1/Cdk2 and inhibition of cell proliferation suggests that the anti-proliferative effects are due, in part, to Cdk inhibition.

An analog of Olomoucine (Cat. No. 495620) that acts as a potent inhibitor of Cdk1 (IC₅₀ = 100 nM) and Cdk2 (IC₅₀ = 80 nM). Also displays anti-proliferative and pro-apoptotic effects.

Biochem/physiol Actions

Cell permeable: no

Primary Target
CDK1, CDK2

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 100 nM, 80 nM, against Cdk1 and Cdk2, respectively

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Vermeulen, K., et al. 2002. Leukemia16, 299.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 10-13 - German Storage Class 10 to 13