219415
Cathepsin Inhibitor I
The Cathepsin Inhibitor I controls the biological activity of Cathepsin. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
Synonym(s):
Cathepsin Inhibitor I, Z-FG-NHO-Bz, CATI -1
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About This Item
Empirical Formula (Hill Notation):
C26H25N3O6
Molecular Weight:
475.49
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
assay
>90% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated
protect from light
color
white
solubility
DMSO: soluble
acetonitrile: soluble
ethanol: soluble
shipped in
ambient
storage temp.
10-30°C
General description
Cell-permeable cysteine protease inhibitor. Inhibits cathepsin B (k2/Ki = 8.9 x 103 M-1 sec-1), cathepsin L (k2/Ki = 3.8 x 105 M-1 sec-1), cathepsin S (k2/Ki = 4.2 x 104 M-1 sec-1), and papain (k2/Ki = 2.4 x 103 M-1 sec-1).
Cysteine protease inhibitor. Selectively inhibits cathepsin B (k2/Ki = 8.9 x 103 M-1sec-1), cathepsin L (k2/Ki = 3.8 x 105 M-1sec-1), cathepsin S (k2/Ki = 4.2 x 104 M-1sec-1), and papain (k2/Ki = 2.4 x 103 M-1sec-1). Half-life in buffered solution (pH 5-9) = 25 h (30°C); 300 h (0°C).
Half-life in buffered solution (pH 5-9) = 25 h (30°C); 300 h (0°C).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
cathepsin B
cathepsin B
Product does not compete with ATP.
Reversible: no
k₂/Ki = 8.9 x 10³ M⁻¹sec⁻¹ for cathepsin B
Warning
Toxicity: Standard Handling (A)
Sequence
Z-Phe-Gly-NHO-Bz
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Zhu, D. and Uckun, F.M. 2000. Clin. Cancer Res.6, 2064.
Demuth, H.-U., et al. 1996. Biochim. Biophys. Acta 1295, 179.
Brömme, D., and Demuth, H.-U. 1994. Methods Enzymol. 244, 671.
Demuth, H.-U., et al. 1996. Biochim. Biophys. Acta 1295, 179.
Brömme, D., and Demuth, H.-U. 1994. Methods Enzymol. 244, 671.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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