P-063
Phenytoin solution
1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
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About This Item
Empirical Formula (Hill Notation):
C15H12N2O2
CAS Number:
Molecular Weight:
252.27
UNSPSC Code:
41116107
NACRES:
NA.24
Recommended Products
grade
certified reference material
form
liquid
feature
Snap-N-Spike®/Snap-N-Shoot®
packaging
ampule of 1 mL
manufacturer/tradename
Cerilliant®
concentration
1.0 mg/mL in methanol
technique(s)
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
application(s)
clinical testing
format
single component solution
storage temp.
−20°C
SMILES string
O=C1NC(=O)C(N1)(c2ccccc2)c3ccccc3
InChI
1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19)
InChI key
CXOFVDLJLONNDW-UHFFFAOYSA-N
Gene Information
human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)
General description
Phenytoin is an antiepileptic drug used in the prevention and treatment of seizures. This analytical reference standard is suitable as starting material for the preparation of calibrators and controls in phenytoin testing by GC/MS or LC-MS/MS. Phenytoin is sold under the trade name Dilantin®.
Application
- Advanced Separation and Extraction of Anticonvulsants: Phenytoin solution is utilized in the fabrication of surface molecularly imprinted polymer membranes. This innovative method enhances the separation and extraction of phenytoin, phenobarbital, and lamotrigine, significantly improving the precision and efficiency of drug monitoring in clinical and research settings (Zhao et al., 2024).
- LC-MS/MS Quantification for Drug Delivery: A sensitive LC-MS/MS method has been developed for the quantification of phenytoin and its major metabolite. This method is applied to both intravenous and intranasal delivery systems, enhancing our understanding of the pharmacokinetics and effectiveness of phenytoin as an anticonvulsant medication (Prentice et al., 2022).
- Clinical Decision Support for Pharmacogenomics: Phenytoin is involved in the appraisal and development of evidence-based clinical decision support systems. This research integrates pharmacogenomic data to optimize perioperative drug use, providing tailored therapeutic strategies based on genetic profiles, particularly for managing epilepsy treatments (Borden et al., 2021).
- Electromembrane Extraction Technique: The development of an electromembrane extraction method followed by capillary electrophoresis for phenytoin determination in exhaled breath condensate. This technique offers a non-invasive approach for therapeutic drug monitoring, critical for ensuring effective seizure control in epilepsy patients (Seyfinejad et al., 2020).
- Drug Crystallization Inhibition: Research into the use of polymer nanogels as reservoirs for phenytoin has shown potential in inhibiting drug crystallization. This approach could revolutionize drug delivery systems by maintaining the stability and bioavailability of phenytoin, enhancing its therapeutic efficacy for treating neurological disorders (Li et al., 2019).
Legal Information
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Dilantin is a registered trademark of Warner-Lambert Co.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
related product
Product No.
Description
Pricing
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
target_organs
Eyes,Central nervous system
Storage Class
3 - Flammable liquids
wgk_germany
WGK 2
flash_point_f
49.5 °F - closed cup
flash_point_c
9.7 °C - closed cup
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Amitava Dasgupta et al.
Journal of clinical laboratory analysis, 27(1), 1-4 (2013-01-18)
For many years, fluorescence polarization immunoassay (FPIA) on the TDx analyzer has been used for determination of free phenytoin concentration. Recently Abbott Laboratories decided to discontinue the TDx analyzer and related assays on this analyzer. Free phenytoin assay is also
Raphael Hösli et al.
Journal of analytical toxicology, 37(2), 102-109 (2013-01-18)
This study describes the development and validation of a gas chromatography-mass spectrometry (GC-MS) method to identify and quantitate phenytoin in brain microdialysate, saliva and blood from human samples. A solid-phase extraction (SPE) was performed with a nonpolar C8-SCX column. The
Elisa Colombo et al.
PloS one, 8(1), e55329-e55329 (2013-02-06)
The persistent Na⁺ current (I(NaP)) is important for neuronal functions and can play a role in several pathologies, although it is small compared to the transient Na⁺ current (I(NaT)). Notably, I(NaP) is not a real persistent current because it undergoes
Kimford J Meador et al.
The Lancet. Neurology, 12(3), 244-252 (2013-01-29)
Many women of childbearing potential take antiepileptic drugs, but the cognitive effects of fetal exposure are uncertain. We aimed to assess effects of commonly used antiepileptic drugs on cognitive outcomes in children up to 6 years of age. In this
B Medhi et al.
Indian journal of physiology and pharmacology, 56(4), 382-387 (2013-06-21)
Esomeprazole is commonly prescribed proton pump inhibitor for gastritis and peptic ulcer disease. Most of the time in clinical practice, phenytoin and esomeprazole are prescribed for patients of generalized seizures with concomitant peptic ulcer. Hence there are chances of drug-drug
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