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870851P

Avanti

C16 Carnitine

Avanti Research™ - A Croda Brand 870851P, powder

Synonym(s):

palmitoyl L-carnitine

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About This Item

Empirical Formula (Hill Notation):
C23H45NO4
CAS Number:
1935-18-8
Molecular Weight:
399.61
UNSPSC Code:
12352211
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 5 mg (870851P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 870851P

lipid type

bioactive lipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

C[N+](C)(C)C[C@H](OC(CCCCCCCCCCCCCCC)=O)CC([O-])=O

InChI

1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3

InChI key

XOMRRQXKHMYMOC-UHFFFAOYSA-N

General description

C16 Carnitine, also called as palmitoyl L-carnitine, is an endogenous acylcarnitine. Structurally, it contains Levocarnitine (L-carnitine) head group and 16 carbon saturated fatty acid tail. Palmitoyl L-carnitine is derived by reversible reaction of palmitoyl-CoA esters with carnitine. Palmitoyl L-carnitine is transported across the inner membrane by carnitine palmitoyl transferase II for β-oxidation.

Application

C16 Carnitine or palmitoyl L-carnitine has been used to study its influence on the glycine transporters activity.

Biochem/physiol Actions

C16 Carnitine has a potential to inhibit glycine transporter 2 (GlyT2). It acts as a key energy donor for β-oxidation. Palmitoyl carnitine activates the Ca2+ release channel of skeletal muscle sarcoplasmic reticulum. Elevated levels of palmitoyl L-carnitine due to palmitoyl transferase II deficiency causes autosomal recessive disorder of energy metabolism, which primarily affects skeletal muscle.

Packaging

5 mL Amber Glass Screw Cap Vial (870851P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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An explorative study of the effect of apple and apple products on the human plasma metabolome investigated by LC--MS profiling
Rago D, et al.
Metabolomics, 11(1), 27-39 (2015)
R el-Hayek et al.
Biophysical journal, 65(2), 779-789 (1993-08-01)
Studies of [3H]ryanodine binding, 45Ca2+ efflux, and single channel recordings in planar bilayers indicated that the fatty acid metabolite palmitoyl carnitine produced a direct stimulation of the Ca2+ release channel (ryanodine receptor) of rabbit and pig skeletal muscle junctional sarcoplasmic
Oleoyl-l-carnitine inhibits glycine transport by G ly T 2
Carland JE, et al.
British Journal of Pharmacology, 168(4), 891-902 (2013)

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