920487
1-((1-(tert-Butoxycarbonyl)azetidin-3-yl)methyl)-1H-pyrazole-3-carboxylic acid
Synonym(s):
Rigid linker for PROTAC® development
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About This Item
Empirical Formula (Hill Notation):
C13H19N3O4
Molecular Weight:
281.31
UNSPSC Code:
12352106
NACRES:
NA.22
Recommended Products
form
powder
Quality Level
reaction suitability
reagent type: linker
functional group
Boc
carboxylic acid
storage temp.
2-8°C
SMILES string
CC(C)(OC(N1CC(C1)CN2C=CC(C(O)=O)=N2)=O)C
Application
1-((1-(tert-Butoxycarbonyl)azetidin-3-yl)methyl)-1H-pyrazole-3-carboxylic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.
Similar linkers in this series:
920495
920576
920584
ADV638390284
Similar linkers in this series:
920495
920576
920584
ADV638390284
Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
related product
Product No.
Description
Pricing
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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