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920401

Sigma-Aldrich

Methoxypolyethylene glycol

average MN 1,000 (by NMR), (Propionic acid), methoxy

Synonym(s):

O-(2-Carboxyethyl)-O′-methylpolyethylene glycol 1,000, PEG acid, PEG carboxylic acid, Polyethylene glycol, mPEG-COOH, mono-Methyl polyethylene glycol 1′000 propionic acid

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About This Item

Linear Formula:
CH3(OCH2CH2)nOCH2CH2COOH
UNSPSC Code:
12352106
NACRES:
NA.23

product name

Methoxypolyethylene glycol 1,000 propionic acid,

form

solid

Quality Level

100

mol wt

average Mn 1,000 (by NMR)

color

white to off-white

Ω-end

(Propionic acid)

α-end

methoxy

polymer architecture

shape: linear
functionality: monofunctional

storage temp.

2-8°C

Application

Methoxypolyethylene glycol 1,000 propionic acid is a pegylation agent used to conjugate proteins to reduce immunogenicity and prolong serum half-life of proteins and enzymes.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Andrea Fajdetić et al.
European journal of medicinal chemistry, 46(8), 3388-3397 (2011-05-24)
Synthesis, antibacterial activity and pharmacokinetic properties of a novel class of macrolide antibiotics-macrolones-derived from azithromycin, comprising oxygen atom(s) in the linker and either free or esterified quinolone 3-carboxylic group, are reported. Selected compounds showed excellent antibacterial potency towards key erythromycin
A Ton J Dirks et al.
Bioconjugate chemistry, 20(6), 1129-1138 (2009-05-21)
The Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) has recently proven to be a powerful synthetic tool in various fields of chemistry, including protein-polymer conjugation. In this article, we describe a fluorogenic CuAAC, which allows for efficient monitoring of protein-polymer conjugation. We show

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