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900860

Sigma-Aldrich

3-Amino-5-ethynylbenzenesulfonyl fluoride

≥95%

Synonym(s):

Amino sulfonyl fluoride alkyne, Probe building block

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About This Item

Empirical Formula (Hill Notation):
C8H6FNO2S
CAS Number:
2088829-09-6
Molecular Weight:
199.20
UNSPSC Code:
12352200
NACRES:
NA.22

assay

≥95%

form

powder or crystals

storage temp.

−20°C

SMILES string

NC1=CC(S(=O)(F)=O)=CC(C#C)=C1

Application

3-Amino-5-ethynylbenzenesulfonyl fluoride is used for chemical probe synthesis, this trifunctional building block contains an aryl sulfonyl fluoride group, alkyne tag, and amine synthetic handle. When appended to a ligand or pharmacophore through its amine linker, this building block allows for SuFEx-enabled, context-specific covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.

Other Notes

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Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Articles

Trifunctional Probe Building Blocks

In partnership with Pfizer chemists, we have compiled a collection of trifunctional building blocks to enable development of probes.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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