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Sigma-Aldrich

Gold nanoparticles

30 nm diameter, carboxylic acid functionalized, PEG 3000 coated, OD 50, dispersion in H2O

Synonym(s):

Gold nanoparticles COOH functionalized, Au NP COOH, Gold Colloid

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About This Item

UNSPSC Code:
12162002
NACRES:
NA.23

material

PEG 3000

form

dispersion in H2O
nanoparticles

packaging

poly bottle of 1 mL

OD

50

diameter

30 nm

pH

6.0-8.0 (25 °C)

solubility

water: miscible

density

1.00 g/cm3

λmax

525 nm

functional group

carboxylic acid

storage temp.

2-8°C

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General description

Carboxylic acid functionalized GNPs forms conjugates with various protein molecules due to the electrostatic attraction between negatively charged carboxylate groups and positively charged amino groups of protein.

Application

Gold nanoparticles 30 nm diameter, carboxylic acid functionalized, PEG 3000 coated, OD 50, dispersion in H2O can be potentially used in the development of biosensors, cancer-cell imaging, drug delivery, and photothermal therapy.
AuNPs may also be used in the immobilization of antibodies to improve the sensitivity of optical fiber sensors for the screening of COVID-19. It can also be deposited on the titanium electrode for the formation of a miniaturized device for the electrochemical detection of DNA hybridization.
The carboxylic acid group binds with various proteins and are used in targeted drug delivery and gene therapy.
Functionalized Particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.

Features and Benefits

Decreases the cytotoxicity and increases efficiency of GNPs in targeted drug delivery. PEG increases the stability of the nanoparticles and prevents agglomeration.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Optical Fiber Sensors for Rapid Screening of COVID-19
Nag P, et al.
Transactions of the Indian National Academy of Engineering, 6, 1-4 (2020)
Nóra Adányi et al.
Food chemistry, 267, 10-14 (2018-06-24)
Mycotoxins, present in a wide range of food and feed commodities, are toxic secondary metabolites produced by a number of different fungi. Certain mycotoxins do not readily degrade at high temperatures, therefore are resistant to food processing, and consequently are
Size-dependent in vivo toxicity of PEG-coated gold nanoparticles
Zhang X, et al.
International journal of nanomedicine, 6, 2071-2071 (2011)
Nishima Wangoo et al.
Journal of colloid and interface science, 323(2), 247-254 (2008-05-20)
We report a novel strategy for the synthesis of aqueous stable, carboxylated gold nanoparticles (GNPs) by using glutamic acid as the reducing agent. The ratio of chloroaurate ions, AuCl(-)(4) to glutamic acid was optimized in the reaction medium to obtain
Functionalized gold nanoparticles and their biomedical applications
Tiwari, P. M., Vig, K., Dennis, V. A., & Singh, S. R.
Nanomaterials, 1(1), 31-63 (2011)

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