Skip to Content
MilliporeSigma
All Photos(1)

Documents

694746

Sigma-Aldrich

Bis(3,5-di(trifluoromethyl)phenyl)chlorophosphine

Synonym(s):

P,P-Bis[3,5-bis(trifluoromethyl)phenyl]phosphinous chloride

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C16H6ClF12P
CAS Number:
Molecular Weight:
492.63
MDL number:
UNSPSC Code:
12352002
PubChem Substance ID:
NACRES:
NA.22

form

solid

reaction suitability

reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: ligand

mp

25-29 °C

functional group

phosphine

SMILES string

FC(F)(F)c1cc(cc(c1)C(F)(F)F)P(Cl)c2cc(cc(c2)C(F)(F)F)C(F)(F)F

InChI

1S/C16H6ClF12P/c17-30(11-3-7(13(18,19)20)1-8(4-11)14(21,22)23)12-5-9(15(24,25)26)2-10(6-12)16(27,28)29/h1-6H

InChI key

DFZQEHBNAJGDCT-UHFFFAOYSA-N

Application

Reactant for synthesis of:
  • Chiral phosphine-aminophosphine ligands for rhodium-catalyzed asymmetric hydrogenation
  • Ligands for palladium-catalyzed stereoselective allylation reactions
  • Ligands for enantioselective hydrogenations
  • Josiphos analog as catalyst for asymmetric hydrogenation
  • Ligands used in asymmetric hydrovinylation reactions

Reactant for enantioselective hydrogenation reactions catalyzed by Ru-(phosphine-oxazoline) complexes

pictograms

FlameCorrosion

signalword

Danger

hcodes

Hazard Classifications

Skin Corr. 1B - Water-react 3

Storage Class

4.3 - Hazardous materials which set free flammable gases upon contact with water

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service