677191

(R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol trimethylsilyl ether

96%

• Synonym(s): (2R)-2-[Diphenyl[(trimethylsilyl)oxy]methyl]pyrrolidine, (R)-α,α-Diphenylprolinol trimethylsilyl ether
• Empirical Formula (Hill Notation): C₂₀H₂₇NOSi
• CAS Number: 943757-71-9
• Molecular Weight: 325.52
• MDL number: MFCD09265100
• UNSPSC Code: 12352005
• PubChem Substance ID: 24885355
• NACRES: NA.22

Properties

• assay: 96%
• form: solid
• optical activity: [α]22/D +52±5°, c = 1 in chloroform
• refractive index: n20/D 1.5509
• density: 1.0459 g/mL at 25 °C
• storage temp.: 2-8°C
• SMILES string: C[Si](C)(C)OC([C@H]1CCCN1)(c2ccccc2)c3ccccc3
• InChI: 1S/C20H27NOSi/c1-23(2,3)22-20(19-15-10-16-21-19,17-11-6-4-7-12-17)18-13-8-5-9-14-18/h4-9,11-14,19,21H,10,15-16H2,1-3H3/t19-/m1/s1
• InChI key: RSUHWMSTWSSNOW-LJQANCHMSA-N

Description

General description

(R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol trimethylsilyl ether is a diarylprolinol silyl ether organocatalyst.

Application

(R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol trimethylsilyl ether can be used as a catalyst to synthesize:

• Glycofused tricyclic derivatives, which are used in the development of amyloid β-peptide diagnostic tools.
• Cyclohexene carbaldehyde derivatives by reacting benzoylnitromethane with aliphatic enals.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves