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655538

Sigma-Aldrich

1,3-Bis(4-carboxyphenoxy)propane

97%

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About This Item

Empirical Formula (Hill Notation):
C17H16O6
CAS Number:
3753-81-9
Molecular Weight:
316.31
MDL number:
MFCD00089995
UNSPSC Code:
12352100
PubChem Substance ID:
24884111
NACRES:
NA.22

assay

97%

form

solid

mp

310 °C (lit.)

SMILES string

OC(=O)c1ccc(OCCCOc2ccc(cc2)C(O)=O)cc1

InChI

1S/C17H16O6/c18-16(19)12-2-6-14(7-3-12)22-10-1-11-23-15-8-4-13(5-9-15)17(20)21/h2-9H,1,10-11H2,(H,18,19)(H,20,21)

InChI key

VBISQLWPGDULSX-UHFFFAOYSA-N

Related Categories

Application

Building block for polyanhydrides, a class of bioerodible polymer with drug delivery applications.

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

hcodes

H317,H400

Hazard Classifications

Aquatic Acute 1 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificates of Analysis (COA)

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A J Domb et al.
Biomaterials, 16(14), 1069-1072 (1995-09-01)
The elimination of a clinically used anticancer biodegradable polymer implant (Gliadel) in the rabbit brain was studied. The implant is composed of N,N-bis(2-chloroethyl)-N-nitrosourea (BCNU) (1.6 wt%) dispersed in a copolyanhydride matrix of 1,3-bis(p-carboxyphenoxypropane) (CPP) and sebacic acid (SA) in a
Urich, K.E. et al.
Macromolecules, 28, 2184-2184 (1995)
A D'Emanuele et al.
Pharmaceutical research, 9(10), 1279-1283 (1992-10-01)
We report a study of the effects of polymer molecular weight on the erosion of polyanhydride copolymer matrices composed of 1,3-bis(p-carboxyphenoxy)-propane (CPP) and sebacic acid (SA) in aqueous solution. The erosion profile characteristically displays an induction period during which the
Sijian Hou et al.
Macromolecular bioscience, 7(5), 620-628 (2007-04-26)
To tailor the erosion rate of polyanhydrides while retaining their surface erosion characteristics, new three-component polyanhydrides of sebacic acid, 1,3-bis(p-carboxyphenoxy)propane and poly(ethylene glycol) were synthesized. The hydrophilicity of the polymer increased and its mechanical strength decreased with increasing PEG content.
Moon Suk Kim et al.
Bio-medical materials and engineering, 15(3), 229-238 (2005-05-25)
p-Carboxyphenoxy propane (CPP) prepolymer consisting of 4 units and sebacic acid (SA) prepolymer consisting of about 10 units were synthesized by reacting CPP and SA in the presence of excess acetic anhydride, respectively. Polyanhydride, poly(CPP-SA) copolymers were copolymerized by a
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