437727

Tetrahydrofuran-d₈

≥99.5 atom % D, contains 0.03 % (v/v) TMS

• Synonym(s): THF-d₈, Deuterated tetrahydrofuran, Octadeuterotetrahydrofuran
• Empirical Formula (Hill Notation): C₄D₈O
• CAS Number: 1693-74-9
• Molecular Weight: 80.16
• Beilstein/REAXYS Number: 111854
• MDL number: MFCD00044238
• UNSPSC Code: 12142201
• PubChem Substance ID: 24867392
• NACRES: NA.21

Properties

• isotopic purity: ≥99.5 atom % D
• assay: ≥99% (CP)
• form: liquid
• contains: 0.03 % (v/v) TMS
• technique(s): NMR: suitable
• impurities: ≤0.03% water; water
• refractive index: n20/D 1.403 (lit.)
• bp: 65-66 °C (lit.)
• mp: −106 °C (lit.)
• density: 0.985 g/mL at 25 °C (lit.)
• mass shift: M+8
• storage temp.: 2-8°C
• SMILES string: [2H]C1([2H])OC([2H])([2H])C([2H])([2H])C1([2H])[2H]
• InChI: 1S/C4H8O/c1-2-4-5-3-1/h1-4H2/i1D2,2D2,3D2,4D2
• InChI key: WYURNTSHIVDZCO-SVYQBANQSA-N

Description

General description

Tetrahydrofuran-d₈ (THF-d₈, TDF) is a deuterated NMR solvent containing 0.03% (v/v) TMS (tetramethylsilane). It is useful in NMR-based research and analyses. ¹H NMR line shape analysis of the exchange rates of proton between methanol and acetic acid dissolved in THF-d₈ was reported. It participates as a solvent in the synthesis of deuteriotris[bis(trimethylsilyl)amido]thorium and deuteriotris[bis(trimethylsiiyl)amido]uranium. Dynamic NMR spectroscopic study of ¹⁵N,¹⁵N′-dipentadeuterophenylformamidine (DPFA) has been studied in THF-d₈.

Application

• Experimental and Theoretical Study of CO2 Insertion into Ruthenium Hydride Complexes.: This research provides insights into the mechanistic pathways for CO2 reactivity with ruthenium hydride complexes, potentially relevant for catalytic applications including transformations involving Tetrahydrofuran-d₈ (Ramakrishnan et al., 2016).



• Syntheses, structures, and NMR chemical shifts of a family of trimethyltin alkoxide, amide, halide and cyclopentadienyl compounds.: Details the synthesis and structural characterization of trimethyltin compounds, useful for understanding the coordination chemistry that may involve Tetrahydrofuran-d₈ as a solvent or structural analogue (Lichtscheidl et al., 2015).


• NMR studies of coupled low- and high-barrier hydrogen bonds in pyridoxal-5′-phosphate model systems in polar solution.: Discusses the application of NMR spectroscopy in studying hydrogen bonding interactions, where Tetrahydrofuran-d₈ could be utilized as a deuterated solvent for enhanced spectral clarity (Sharif et al., 2007).



• Stable hydrocarbon diradical, an analogue of trimethylenemethane.: Investigates stable hydrocarbon diradicals, where Tetrahydrofuran-d₈ may be used as part of the experimental setup to stabilize reactive intermediates or as a solvent to study radical stability (Rajca et al., 2005).

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Safety Information

• pictograms: GHS02,GHS08,GHS07
• signalword: Danger
• hcodes: H225,H302,H319,H335,H336,H351
• pcodes: P202 - P210 - P233 - P301 + P312 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
• target_organs: Central nervous system, Respiratory system
• supp_hazards: EUH019
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 1
• flash_point_f: 1.4 °F - closed cup
• flash_point_c: -17 °C - closed cup