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Sigma-Aldrich

4-Bromo-2-chloro-1-fluorobenzene

99%

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About This Item

Linear Formula:
BrC6H3(Cl)F
CAS Number:
60811-21-4
Molecular Weight:
209.44
EC Number:
405-580-2
MDL number:
MFCD00051794
UNSPSC Code:
12352100
PubChem Substance ID:
24867080
NACRES:
NA.22

assay

99%

form

liquid

refractive index

n20/D 1.553 (lit.)

bp

194 °C (lit.)

density

1.727 g/mL at 25 °C (lit.)

SMILES string

Fc1ccc(Br)cc1Cl

InChI

1S/C6H3BrClF/c7-4-1-2-6(9)5(8)3-4/h1-3H

InChI key

CJTIWGBQCVYTQE-UHFFFAOYSA-N

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Application

4-Bromo-2-chloro-1-fluorobenzene may be used for the preparation of 2-(3-chloro-4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Irrit. 2

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

192.2 °F - closed cup

flash_point_c

89 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Certificates of Analysis (COA)

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Mark S Jensen et al.
The Journal of organic chemistry, 70(15), 6034-6039 (2005-07-16)
A practical synthesis of 2-[3-(4-fluoro-3-pyridin-3-yl-phenyl)-imidazo[1,2-a]pyrimidin-7-yl]-propan-2-ol (1), an oral GABA(A) alpha(2/3)-selective agonist, is described. The five-step process, which afforded 1 in 40% overall yield, included imidazopyrimidine 2 and pyridine boronic acid 4 as key fragments. The synthesis is highlighted by consecutive
James A Newby et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 20(1), 263-271 (2013-12-18)
Conducting low-temperature organometallic reactions under continuous flow conditions offers the potential to more accurately control exotherms and thus provide more reproducible and scalable processes. Herein, progress towards this goal with regards to the lithium-halogen exchange/borylation reaction is reported. In addition

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