Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

View All Documentation

399000

Sigma-Aldrich

2,2,2-Trifluoroethyl butyrate

98%

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Linear Formula:
CH3CH2CH2COOCH2CF3
CAS Number:
371-27-7
Molecular Weight:
170.13
Beilstein/REAXYS Number:
1769212
MDL number:
MFCD00077609
UNSPSC Code:
12352100
PubChem Substance ID:
24864780

assay

98%

refractive index

n20/D 1.347 (lit.)

bp

113 °C/747 mmHg (lit.)

density

1.127 g/mL at 25 °C (lit.)

SMILES string

CCCC(=O)OCC(F)(F)F

InChI

1S/C6H9F3O2/c1-2-3-5(10)11-4-6(7,8)9/h2-4H2,1H3

InChI key

DEXWRCYOMLUJRF-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

General description

Solvent effects on porcine pancreatic lipase-catalyzed transesterification of 2,2,2-trifluoroethyl butyrate has been studied.[1] Kinetics of the reaction of OH radicals and Cl atoms with 2,2,2 trifluoroethyl butyrate has been reported.[2]

Application

2,2,2-Trifluoroethyl butyrate may be used in the lipase catalyzed resolution of unsubstituted and N-alkyl substituted 2-amino-1-phenylethanols.[3] It may be used in the synthesis of enantiomerically pure (R)- or (S)-1-aminoindane.[4]

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

3 - Flammable liquids

wgk_germany

WGK 3

flash_point_f

69.8 °F - closed cup

flash_point_c

21 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
BCBQ1333V
BCBJ7430V
1396435
U16868
04105KN

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Tropospheric degradation of 2, 2, 2 trifluoroethyl butyrate: Kinetic study of their reactions with OH radicals and Cl atoms at 298K.
Blanco MB, et al.
Chemical Physics Letters, 578, 33-37 (2013)
Lipase catalysis in the optical resolution of 2-amino-1-phenylethanol derivatives.
Kanerva LT, et al.
Journal of the Chemical Society. Perkin Transactions 1, 14, 1759-1762 (1992)
W H Boesten et al.
Organic letters, 3(8), 1121-1124 (2001-05-12)
[reaction: see text]. Diastereoselective Strecker reactions based on (R)-phenylglycine amide as chiral auxiliary are reported. The Strecker reaction is accompanied by an in situ crystallization-induced asymmetric transformation, whereby one diastereomer selectively precipitates and can be isolated in 76-93% yield and
L T Kanerva et al.
Acta chemica Scandinavica (Copenhagen, Denmark : 1989), 44(10), 1032-1035 (1990-11-01)
Porcine pancreatic lipase-catalysed transesterifications of 2,2,2-trifluoroethyl butyrate with racemic 2-octanol and 1-phenylethanol have been studied in different organic solvents. Solvent hydrophobicity (log P -1.1 to 3.3) has only a minor effect on the reaction rate. Independently of the solvent used

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service