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9,10-Dihydrolysergol

Name: 9,10-Dihydrolysergol
Brand: ALDRICH

97%

Synonym(s):

6-Methylergoline-8β-methanol

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₂₀N₂O

CAS Number:

18051-16-6

Molecular Weight:

256.34

MDL number:

MFCD00134437

UNSPSC Code:

12352103

assay

97%

SMILES string

CN1C[C@H](CO)C[C@H]2[C@H]1Cc3c[nH]c4cccc2c34

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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[Synthesis of glycosides and sugar orthoesters of 9,10-dihydrolysergol].

K Seifert et al.

Archiv der Pharmazie, 317(7), 577-583 (1984-07-01)

Cycloalkanecarboxylic esters derived from lysergol, dihydrolysergol-I, and elymoclavine as partial agonists and antagonists at rat 5-HT2A receptors: pharmacological evidence that the indolo[4,3-fg]quinoline system of the ergolines is responsible for high 5-HT2A receptor affinity.

H H Pertz et al.

Journal of medicinal chemistry, 42(4), 659-668 (1999-03-03)

Three series of cycloalkanecarboxylic esters derived from the naturally occurring clavine alkaloids lysergol, dihydrolysergol-I, and elymoclavine were synthesized to study their interaction with 5-HT2A receptors and alpha1-adrenoceptors in rat tail artery and aorta, respectively. Especially cycloalkanecarboxylic esters derived from lysergol

O-acylated lysergol and dihydrolysergol-I derivatives as competitive antagonists of 5-HT at 5-HT2 receptors of rat tail artery. Allosteric modulation instead of pseudoirreversible inhibition.

H Pertz et al.

Naunyn-Schmiedeberg's archives of pharmacology, 345(4), 394-401 (1992-04-01)

Twelve ergolines (O-acylated lysergol and dihydrolysergol-I derivatives) were synthesized to study their antagonism of 5-HT responses in comparison with methylsergide and LY 53857 [6-methyl-1-(1-methylethyl)-8 beta-ergoline carboxylic acid 2-hydroxy-1-methylpropyl-ester hydrogen maleate] in cylindrical segments of the isolated rat tail artery. With

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