Skip to Content
MilliporeSigma
All Photos(1)

Documents

337633

Sigma-Aldrich

4-Chloro-2,8-bis(trifluoromethyl)quinoline

97%

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C11H4ClF6N
CAS Number:
83012-13-9
Molecular Weight:
299.60
EC Number:
280-132-5
MDL number:
MFCD00075104
UNSPSC Code:
12352100
PubChem Substance ID:
24860490

assay

97%

mp

46-48 °C (lit.)

SMILES string

FC(F)(F)c1cc(Cl)c2cccc(c2n1)C(F)(F)F

InChI

1S/C11H4ClF6N/c12-7-4-8(11(16,17)18)19-9-5(7)2-1-3-6(9)10(13,14)15/h1-4H

InChI key

ZSQOESPYYNJBCZ-UHFFFAOYSA-N

General description

4-Chloro-2,8-bis(trifluoromethyl)quinolone is the intermediate formed during the synthesis of quinoline derivatives.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

235.4 °F - closed cup

flash_point_c

113 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Sumesh Eswaran et al.
European journal of medicinal chemistry, 45(8), 3374-3383 (2010-06-12)
Four new series of quinoline derivatives were synthesized starting from 2-trifluoromethyl aniline through multi-step reactions. In the reaction sequence, substituted aniline was cyclized to 4-hydroxy quinoline 1, which was then transformed to 4-chloro-2,8-bis(trifluoromethyl)quinoline 2. The key scaffold 4-hydrazinyl-2,8-bis(trifluoromethyl)quinoline 3, obtained

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service