263613

Diethyl chloromethylphosphonate

97%

• Synonym(s): Chloromethylphosphonic acid diethyl ester, NSC 67753
• Linear Formula: ClCH₂PO(OC₂H₅)₂
• CAS Number: 3167-63-3
• Molecular Weight: 186.57
• Beilstein/REAXYS Number: 1363361
• EC Number: 221-632-5
• MDL number: MFCD00010189
• UNSPSC Code: 12352101
• PubChem Substance ID: 24855986

Properties

• assay: 97%
• reaction suitability: reaction type: C-C Bond Formation
• refractive index: n20/D 1.437 (lit.)
• bp: 109-110 °C/10 mmHg (lit.)
• density: 1.2 g/mL at 25 °C (lit.)
• SMILES string: CCOP(=O)(CCl)OCC
• InChI: 1S/C5H12ClO3P/c1-3-8-10(7,5-6)9-4-2/h3-5H2,1-2H3
• InChI key: MZBIWKMCTWJLPT-UHFFFAOYSA-N

Description

application

Reactant involved in:

• Subsequent alkylation after nucleophilic substitution
• One-pot alkylation-boration of α-haloalkylphosphonates
• Synthesis of cyclpentane and pyrrolidine derivatives via regioselective insertion reactions
• Phosphorylation leading to P-containing cyclopropanes
• Wadsworth-Emmons reactions
• Ring expansion of zircnacycles via carbenoid insertion

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3
• flash_point_f: 186.8 °F - closed cup
• flash_point_c: 86 °C - closed cup
• ppe: Eyeshields, Gloves, type ABEK (EN14387) respirator filter