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224235

Sigma-Aldrich

N,N′-Hexamethylene bis(acetamide)

98%

Synonym(s):

N,N′-Diacetyl-1,6-hexanediamine, HMBA

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About This Item

Linear Formula:
CH3CONH(CH2)6NHCOCH3
CAS Number:
3073-59-4
Molecular Weight:
200.28
MDL number:
MFCD00008684
UNSPSC Code:
12352100
PubChem Substance ID:
24853423
NACRES:
NA.22

assay

98%

mp

128-129 °C (lit.)

solubility

water: soluble 5%, clear, colorless

SMILES string

CC(=O)NCCCCCCNC(C)=O

InChI

1S/C10H20N2O2/c1-9(13)11-7-5-3-4-6-8-12-10(2)14/h3-8H2,1-2H3,(H,11,13)(H,12,14)

InChI key

BNQSTAOJRULKNX-UHFFFAOYSA-N

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Application

N,N′-Hexamethylene bis(acetamide) was used as an inducing agent in obtaining mononuclear cells from the peripheral blood (PB) sample by Ficoll-Hypaque gradient separation.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Xuguang Zhu et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 23(2), 430-440 (2016-07-22)
New therapeutic approaches are needed for patients with thyroid cancer refractory to radioiodine treatment. An inhibitor of bromodomain and extraterminal domain (BET) proteins, JQ1, shows potent antitumor effects in hematological cancers and solid tumors. To evaluate whether JQ1 is effective
Maria Chatzopoulou et al.
European journal of medicinal chemistry, 50, 75-80 (2012-02-22)
Based on previous studies on bis-acetamides that act as hybrid polar compounds to induce leukemia cell differentiation, an attempt was made to bioisosterically replace the amide moiety with the lipophilic non-classical bioisostere tetrazole. A pyrrole group was also included in
Richard L Thompson et al.
PLoS pathogens, 5(3), e1000352-e1000352 (2009-03-28)
The mechanism controlling the exit from herpes simplex virus latency (HSV) is of central importance to recurrent disease and transmission of infection, yet interactions between host and viral functions that govern this process remain unclear. The cascade of HSV gene
Shailesh K Choudhary et al.
The Journal of infectious diseases, 197(8), 1162-1170 (2008-04-19)
Novel therapeutic approaches are needed to attack persistent proviral human immunodeficiency type 1 (HIV-1) infection. Hexamethylbisacetamide (HMBA), a hybrid bipolar compound, induces expression of the HIV-1 promoter in the long terminal repeat (LTR) region in a Tat-independent manner but mimics
Kara G Lassen et al.
PloS one, 7(1), e30176-e30176 (2012-02-01)
Latently infected cells form the major obstacle to HIV eradication. Studies of HIV latency have been generally hindered by the lack of a robust and rapidly deployable cell model that involves primary human CD4 T lymphocytes. Latently infected cell lines
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