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Sigma-Aldrich

N,O-Bis(trimethylsilyl)trifluoroacetamide

≥99%

Synonym(s):

BSTFA

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$104.00
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$371.00

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5 G
$37.50
25 G
$104.00
100 G
$371.00

About This Item

Linear Formula:
CF3C[=NSi(CH3)3]OSi(CH3)3
CAS Number:
Molecular Weight:
257.40
Beilstein/REAXYS Number:
2050024
EC Number:
MDL number:
UNSPSC Code:
12352111
PubChem Substance ID:
NACRES:
NA.22

$37.50


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grade

synthesis grade

Quality Level

assay

≥99%

form

liquid

refractive index

n20/D 1.384 (lit.)

bp

45-50 °C/14 mmHg (lit.)

density

0.969 g/mL at 25 °C (lit.)

functional group

fluoro

SMILES string

C[Si](C)(C)O\C(=N\[Si](C)(C)C)C(F)(F)F

InChI

1S/C8H18F3NOSi2/c1-14(2,3)12-7(8(9,10)11)13-15(4,5)6/h1-6H3/b12-7+

InChI key

XCOBLONWWXQEBS-KPKJPENVSA-N

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General description

N,O-Bis(trimethylsilyl)trifluoroacetamide is an organosilicon reagent for trimethylsilylation, deprotection, dehydrogenation, allylic alkylation, nitronate formation, and Claisen rearrangement.

BSTFA is a silylating agent used in the synthesis of 4-Quinolones.[1]

Application

N,O-Bis(trimethylsilyl)trifluoroacetamide can be used as a derivatization reagent for the determination of the estrogens estrone and 17α-ethinylestradiol by gas chromatography-mass spectrometry.

pictograms

FlameExclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2

Storage Class

3 - Flammable liquids

wgk_germany

WGK 3

flash_point_f

93.2 °F

flash_point_c

34 °C

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter


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Synthesis of 4-Quinolones: N, O-Bis (trimethylsilyl) acetamide-Mediated Cyclization with Cleavage of Aromatic C--O Bond
Pisa O, et al.
European Journal of Organic Chemistry, 2016, 2336-2350 (2016)
Ahmed I Rushdi et al.
SpringerPlus, 3, 253-253 (2014-06-14)
Propolis is a sticky material mixed by honeybees to utilize it in protecting their hives from infection by bacteria and fungi. The therapeutic properties of propolis are due to its chemical composition with bio-active compounds; therefore, researchers are interested in
E Teixidó et al.
Journal of chromatography. A, 1135(1), 85-90 (2006-10-03)
A new, simple and selective method for the analysis of 5-hydroxymethylfurfural (HMF) in foods by gas chromatography coupled to mass spectrometry (GC-MS) is proposed. Several derivatising procedures based on the formation of an HMF silylated derivative using different reagents were
Hidenori Matsukami et al.
The Science of the total environment, 493, 672-681 (2014-07-06)
Chlorinated and non-halogenated organophosphorus flame retardants (OPFRs) including tris(2-chloroisopropyl) phosphate (TCIPP), diethylene glycol bis(di(2-chloroisopropyl) phosphate) (DEG-BDCIPP), triphenyl phosphate (TPHP), and bisphenol A bis(diphenyl phosphate) (BPA-BDPP) have been used increasingly as alternatives to polybrominated diphenyl ethers and other brominated flame retardants.
Nyi Nyi Naing et al.
Journal of chromatography. A, 1423, 1-8 (2015-11-05)
Electro membrane extraction-solid-liquid phase microextraction (EME-SLPME) was developed for the first time to determine phenolic contaminants in water. The extraction system consisted of a solid/liquid interface that permitted a three-phase microextraction approach involving an aqueous sample (donor phase): an organic

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    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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