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145963

Sigma-Aldrich

Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate

98%

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About This Item

Empirical Formula (Hill Notation):
C8H9ClN2O2S
CAS Number:
5909-24-0
Molecular Weight:
232.69
EC Number:
227-619-0
MDL number:
MFCD00006085
UNSPSC Code:
12352100
PubChem Substance ID:
24848754
NACRES:
NA.22

assay

98%

form

powder

mp

60-63 °C (lit.)

storage temp.

2-8°C

SMILES string

CCOC(=O)c1cnc(SC)nc1Cl

InChI

1S/C8H9ClN2O2S/c1-3-13-7(12)5-4-10-8(14-2)11-6(5)9/h4H,3H2,1-2H3

InChI key

SNNHLSHDDGJVDM-UHFFFAOYSA-N

Application

Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate was used in the synthesis of pyrimidinopyridones, potential inhibitors of the FMS tyrosine kinase.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Hui Huang et al.
Bioorganic & medicinal chemistry letters, 18(7), 2355-2361 (2008-03-18)
A series of pyrimidinopyridones has been designed, synthesized and shown to be potent and selective inhibitors of the FMS tyrosine kinase. Introduction of an amide substituent at the 6-position of the pyridone core resulted in a significant potency increase. Compound

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