Skip to Content
MilliporeSigma
All Photos(2)

Key Documents

View All Documentation

108456

Sigma-Aldrich

Trimethyl orthoformate

99%

Synonym(s):

Trimethoxymethane

Sign Into View Organizational & Contract Pricing

Select a Size

500 ML
$120.00
20 L
$1,260.00

$120.00

Available to ship onApril 22, 2025Details

Request a Bulk Order
All Photos(2)

Select a Size

Change View
500 ML
$120.00
20 L
$1,260.00

About This Item

Linear Formula:
CH(OCH3)3
CAS Number:
149-73-5
Molecular Weight:
106.12
Beilstein/REAXYS Number:
969215
EC Number:
205-745-7
MDL number:
MFCD00008483
UNSPSC Code:
12352100
eCl@ss:
39021015
PubChem Substance ID:
24846805
NACRES:
NA.22

$120.00

Available to ship onApril 22, 2025Details

Request a Bulk Order

vapor density

3.67 (vs air)

Quality Level

200

vapor pressure

23.5 mmHg ( 20 °C)
40 mmHg ( 30 °C)
57 mmHg ( 40 °C)

assay

99%

expl. lim.

5.1 %

refractive index

n20/D 1.379 (lit.)

bp

101-102 °C (lit.)

density

0.97 g/mL at 25 °C (lit.)

functional group

ether

SMILES string

COC(OC)OC

InChI

1S/C4H10O3/c1-5-4(6-2)7-3/h4H,1-3H3

InChI key

PYOKUURKVVELLB-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

Trimethyl orthoformate is an effective solvent for thallium(III) nitrate-mediated oxidations[1]. It undergoes acid catalyzed reaction with 6-(N-D-ribitylanilino) uracils to form 8-demethyl-8-hydroxy-5-deazariboflavins[2].

Application

Trimethyl orthoformate was used as dehydrating agent in the preparation of surface-modified colloidal silica nanoparticles[3].

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

3 - Flammable liquids

wgk_germany

WGK 1

flash_point_f

55.4 °F - closed cup

flash_point_c

13 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
SHBR4424
STBL3102
SHBR3090
BCCJ4081
MKCQ9299

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

P F Holmes et al.
Journal of biomedical materials research. Part A, 91(3), 824-833 (2008-12-04)
The synthesis of surface-modified silica nanoparticles, chemically grafted with acrylate and poly(ethylene glycol) (PEG) groups, and the ability of the resulting crosslinked coatings to inhibit protein adsorption and bacterial adhesion are explored. Water contact angles, nanoindentation, and atomic force microscopy
Tilman Läppchen et al.
EJNMMI physics, 7(1), 22-22 (2020-04-24)
For multicenter clinical studies, PET/CT and SPECT/CT scanners need to be validated to ensure comparability between various scanner types and brands. This validation is usually performed using hollow phantoms filled with radioactive liquids. In recent years, 3D printing technology has
Synthesis of 8-demethyl-8-hydroxy-5-deazariboflavins
Ashton WT and Brown RD
Journal of Heterocyclic Chemistry, 17(8), 1709-1712 (1980)
Thallium in organic synthesis. 43. Novel oxidative rearrangements with thallium (III) nitrate (TTN) in trimethyl orthoformate (TMOF).
Taylor EC, et al.
Journal of the American Chemical Society, 98(10), 3037-3038 (1976)
Stefan Oelmann et al.
Biomacromolecules, 20(1), 90-101 (2018-06-06)
A Passerini three-component polymerization was performed for the synthesis of amphiphilic star-shaped block copolymers with hydrophobic cores and hydrophilic coronae. The degree of polymerization of the hydrophobic core was varied from 5 to 10 repeating units, and the side chain
View All Related Papers

Questions

1–2 of 2 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service