TNNT3
troponin T type 3 (skeletal, fast)
Synonyms:
TNTF
Species:
Human TNNT3 (7140), Mouse Tnnt3 (21957), Rat Tnnt3 (24838), domestic guinea pig Tnnt3 (100734707), Goat TNNT3 (100861247), dog TNNT3 (475996), Domestic Rabbit TNNT3 (100009527), cow TNNT3 (282096), naked mole-rat Tnnt3 (101718573), sheep TNNT3 (101104467) ...More
UniProtKB ID:
Gene ID:
- Human(7140) Summary: The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B). [provided by RefSeq, Oct 2009]
- Mouse(21957) troponin T3, skeletal, fast
- Rat(24838) troponin T type 3 (skeletal, fast)
- domestic guinea pig(100734707) troponin T type 3 (skeletal, fast)
- Goat(100861247) troponin T type 3 (skeletal, fast)
- dog(475996) troponin T type 3 (skeletal, fast)
- Domestic Rabbit(100009527) troponin T type 3 (skeletal, fast)
- cow(282096) troponin T type 3 (skeletal, fast)
- naked mole-rat(101718573) troponin T type 3 (skeletal, fast)
- sheep(101104467) troponin T type 3 (skeletal, fast)
- domestic cat(101091149) troponin T type 3 (skeletal, fast)
- chicken(395761) troponin T type 3 (skeletal, fast)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-TNNT3 antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
bovine, dog, goat, guinea pig, horse, human, mouse, rabbit, rat
Application
western blot
Anti-TNNT3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Monoclonal Anti-TNNT3, (C-terminal) antibody produced in mouse, clone 1H4, ascites fluid,
Species Reactivity
human, rat
Application
ELISA
western blot
western blot
Anti-TNNT3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Monoclonal Anti-Troponin T antibody produced in mouse, clone JLT-12, ascites fluid,
Species Reactivity
bovine, chicken, rabbit, rat
Application
immunohistochemistry
western blot
western blot
esiRNA
Product Number
Description
Species